Evidence map›Paper›PMID 35892200›Full record

ReviewOpen biology2022

Mapping molecular complexes with super-resolution microscopy and single-particle analysis.

Afonso Mendes, Hannah S Heil, Simao Coelho, Christophe Leterrier, Ricardo Henriques

Abstract readReview
In one paragraph

Review in Open biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Advances in Cellular and Molecular Biology Assays: A Review of Gold Standard Methods.International journal of innovative science and research technology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Afonso MendesInstituto Gulbenkian de Ciência, Oeiras, Portugal.ORCID 0000-0001-7324-555X
Hannah S HeilInstituto Gulbenkian de Ciência, Oeiras, Portugal.ORCID 0000-0003-4279-7022
Simao CoelhoInstituto Gulbenkian de Ciência, Oeiras, Portugal.ORCID 0000-0002-0763-3172
Christophe LeterrierAix Marseille Université, CNRS, INP UMR7051, NeuroCyto, Marseille, France.ORCID 0000-0002-2957-2032
Ricardo HenriquesInstituto Gulbenkian de Ciência, Oeiras, Portugal.ORCID 0000-0002-2043-5234

Funding

European Research Council 101001332Wellcome Trust 203276/Z/16/Z
6 · The paper itself

Abstract

Understanding the structure of supramolecular complexes provides insight into their functional capabilities and how they can be modulated in the context of disease. Super-resolution microscopy (SRM) excels in performing this task by resolving ultrastructural details at the nanoscale with molecular specificity. However, technical limitations, such as underlabelling, preclude its ability to provide complete structures. Single-particle analysis (SPA) overcomes this limitation by combining information from multiple images of identical structures and producing an averaged model, effectively enhancing the resolution and coverage of image reconstructions. This review highlights important studies using SRM-SPA, demonstrating how it broadens our knowledge by elucidating features of key biological structures with unprecedented detail.

Indexed as

Microscopy, Fluorescencesingle-particle analysisstructural biologysuper-resolution microscopy

Identifiers

PMID35892200
PMCPMC9326279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.