Evidence map›Paper›PMID 35892131›Full record

ArticleThe Journal of infectious diseases2022

Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection.

Yu Kato, Nathaniel I Bloom, Peifang Sun, Corey A Balinsky, Qi Qiu, Ying Cheng, Vihasi Jani, Megan A Schilling, Carl W Goforth, Dawn L Weir and 4 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
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  4. Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024
    Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yu KatoCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Nathaniel I BloomCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Peifang SunNaval Medical Research Center, Silver Spring, Maryland, USA.
Corey A BalinskyHenry Jackson Foundation, Bethesda, Maryland, USA.
Qi QiuHenry Jackson Foundation, Bethesda, Maryland, USA.
Ying ChengLeidos, Reston, Virginia, USA.
Vihasi JaniHenry Jackson Foundation, Bethesda, Maryland, USA.
Megan A SchillingNaval Medical Research Center, Silver Spring, Maryland, USA.
Carl W GoforthNaval Medical Research Center, Silver Spring, Maryland, USA.
Dawn L WeirNaval Medical Research Center, Silver Spring, Maryland, USA.
Irene RamosDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Stuart C SealfonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Andrew G LetiziaNaval Medical Research Center, Silver Spring, Maryland, USA.ORCID 0000-0002-7361-5917
Shane CrottyCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe development of memory B cells after asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well understood.

methodsWe compared spike antibody titers, pseudovirus neutralizing antibody titers, and memory B-cell responses among SARS-CoV-2 PCR-positive Marine recruits who either reported asymptomatic or symptomatic infection.

resultsThirty-six asymptomatic participants exhibited similar spike IgG titers, spike IgA titers, and pseudovirus neutralization titers compared to 30 symptomatic participants. Pseudovirus neutralization and spike IgG titers showed significant positive correlations with frequency of memory B cells.

conclusionsAmong young adults, asymptomatic SARS-CoV-2 infection induced antibody and memory B-cell responses comparable to mild symptomatic infection.

Indexed as

COVID-19Antibodies, NeutralizingAntibodies, ViralHumansImmunoglobulin GSARS-CoV-2Spike Glycoprotein, CoronavirusYoung AdultAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2adaptive immune responseasymptomatic infectionCOVID-19 immunitymemory B cellsmild infectionSARS-CoV-2

Identifiers

PMID35892131
PMCPMC9384564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.