ArticleKardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery2022
Computed tomography-guided lung biopsy for molecular tests: a meta-analysis.
Article in Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Computed tomography-guided biopsy for pulmonary nodules: comparison between with and without coaxial technique.Journal of cardiothoracic surgery · 2026Article
- Construction and validation of an EGFR-related risk signature identifiedTranslational cancer research · 2025Article
- Comparison of computed tomography-guided core needle biopsy of pulmonary nodules performed with and without the coaxial technique.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Article
- Ultrasound versus computed tomography guided percutaneous needle biopsy for subpleural pulmonary lesions.Frontiers in oncology · 2024Article
- Simultaneous percutaneous microwave ablation and biopsy for highly suspected malignant pulmonary nodules: a retrospective cohort study.Quantitative imaging in medicine and surgery · 2023Article
- Acquiring tissue for advanced lung cancer diagnosis and comprehensive biomarker testing: A National Lung Cancer Roundtable best-practice guide.CA: a cancer journal for cliniciansArticle
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Authors and funding
4 authors.
Funding
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Abstract
Introduction: Computed tomography (CT)-guided lung biopsy has been widely used for molecular testing. Aim: To evaluate the potential clinical effectiveness of computed tomography (CT)-guided lung biopsy in molecular tests. Material and methods: We searched the related studies from the PubMed, Embase, and Cochrane Library until July 2021. The endpoints included adequacy rates for molecular tests, positive rates of epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) translocation, and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. Results: Initially, we were able to identify 1783 potentially relevant studies, among which only 12 were ultimately included in the present meta-analysis. All the studies were retrospective in nature. A total of 2559 patients underwent CT-guided lung biopsy and 1414 of them received molecular testing. We found that the pooled adequacy rate for molecular tests, positive rate of EGFR mutations, and positive rate of ALK translocation were 95%, 49%, and 7%, respectively. Significant heterogeneity was detected in the endpoints of adequacy rate for molecular tests ( Conclusions: CT-guided lung biopsy can serve as an effective method to provide sufficient lung cancer samples for molecular testing. The EGFR gene was found to be the most frequently mutated during the analysis.
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