Evidence map›Paper›PMID 35891836›Full record

ArticleCureus2022

The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome.

Aykut Kemanci, Tarik Goren, Mehmet Uluturk, Atakan Yilmaz, Ramazan Sabirli, Mert Ozen, Murat Seyit, Alten Oskay, Aylin Koseler, Ibrahim Turkcuer

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Aykut KemanciEmergency Medicine, Tavsanli Doc. Dr. Mustafa Kalemli State Hospital, Kutahya, TUR.
Tarik GorenEmergency Department, Medical Faculty, Pamukkale University, Deni̇zli̇, TUR.
Mehmet UluturkEmergency Department, Medical Faculty, Pamukkale University, Deni̇zli̇, TUR.
Atakan YilmazEmergency Department, Medical Faculty, Pamukkale University, Denizli, TUR.
Ramazan SabirliEmergency Department, Bakircay University Faculty of Medicine Cigli Training and Research Hospital, Izmir, TUR.
Mert OzenEmergency Department, Medical Faculty, Pamukkale University, Denizli, TUR.
Murat SeyitEmergency Department, Medical Faculty, Pamukkale University, Denizli, TUR.
Alten OskayEmergency Department, Medical Faculty, Pamukkale University, Denizli, TUR.
Aylin KoselerBiophysics Department, Medical Faculty, Pamukkale University, Denizli, TUR.
Ibrahim TurkcuerEmergency Department, Medical Faculty, Pamukkale University, Denizli, TUR.
Izmir University · TRState Hospital · GBPamukkale University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to evaluate the relationship between peroxisome proliferator-activated receptor (PPAR) alpha and gamma gene polymorphisms and acute coronary syndrome (ACS) clinically. SUBJECT AND

methodsPeripheral blood samples were collected from a total of 200 people, including 100 acute coronary syndrome patients and 100 controls aged 19 to 93 years, admitted to the Pamukkale University Emergency Medicine Department. The healthy volunteers had no known chronic or acute diseases, no history of drug use, and no recent history of coronary artery disease (CAD). PPAR alpha L162V and PPAR gamma C161T gene polymorphic regions were detected using DNA sequencing analyses. In addition, data collected from the hemogram and biochemical parameters and comorbidities of the patients were statistically analyzed.

resultsPPAR gamma C161T polymorphisms were compared between groups. The CT heterozygous rate in the patient group (74%) was higher than in the control group (7%). The T allele was more common in the patient group (0.37) compared to the control group (0.03). When PPAR alpha L162V polymorphism was compared, VV homozygous individuals were %19 in the patient group and none in the control group. The V allele was found to be statistically higher in patients with ACS (p<0.01).

conclusionThe findings revealed that elevated PPAR alpha L162V and PPAR gamma C161T gene polymorphisms were associated with a progressive risk of ACS.

Indexed as

acute coronary syndromecoronary heart diseasemutationpolymorphismppar alphappar gamma

Identifiers

PMID35891836
PMCPMC9301886
OpenAlexW4283364744

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.