Clinical and Genetic Characteristics of Preeclampsia.

O V Golovchenko, M Y Abramova, V S Orlova, I V Batlutskaya, I N Sorokina

Open access · greenAbstract read

In one paragraph

Article in Archives of Razi Institute, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

1.5field-weighted citation impact, top 18% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

Effect of the Dietary Approaches to Stop Hypertension (DASH) diet on the development of preeclampsia and metabolic outcomes in pregnant women with pre-existing diabetes mellitus: a randomised, controlled, single-blind trial.Journal of nutritional science · 2023
Trial
Effect of Compound Danshen Injection Combined with Magnesium Sulfate on Oxidative Stress, TNF-Computational intelligence and neuroscience · 2022
Trial
Renal Function and the Role of the Renin-Angiotensin-Aldosterone System (RAAS) in Normal Pregnancy and Pre-Eclampsia.Journal of clinical medicine · 2025
Review
SIRT3 inhibits autophagy-dependent ferroptosis of HUVECs in the progression of pregnancy-induced hypertension by activating the PI3K/Akt/mTOR axis.Frontiers in molecular neuroscience · 2025
Article
Biomarkers and point of care screening approaches for the management of preeclampsia.Communications medicine · 2024
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

O V GolovchenkoBelgorod State University, 308015, Belgorod, Pobeda Street, 85, Russia.

M Y AbramovaBelgorod State University, 308015, Belgorod, Pobeda Street, 85, Russia.

V S OrlovaBelgorod State University, 308015, Belgorod, Pobeda Street, 85, Russia.

I V BatlutskayaBelgorod State University, 308015, Belgorod, Pobeda Street, 85, Russia.

I N SorokinaBelgorod State University, 308015, Belgorod, Pobeda Street, 85, Russia.

Belgorod National Research University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preeclampsia (PE) is a severe complication of pregnancy accompanied by arterial hypertension, edema, or proteinuria with impaired functioning of various organs and systems. It is also an important medical and social problem, which has been one of the leading causes of maternal and perinatal mortality and morbidity worldwide. Despite the achievements of modern medicine, the etiology of this pathology is still unknown. Recently, many scientists have especially focused on the study of genetic factors underlying the etiopathogenesis of PE, namely, the contribution of individual polymorphic loci of various candidate genes. The current study aimed to investigate the clinical characteristics of PE and the contribution of the polymorphic loci rs1042838 of Progesterone Receptor (PGR) gene and rs8068318 of the T-Box Transcription Factor 2 (TBX2) gene to the development of PE. The study was conducted on 219 women with PE with the mean±SD age of 26.52±5.51 years and 329 women with the physiological course of pregnancy as the control group with the mean±SD age of 26.27±4.88 years. In total, 64.20%, 68.29%, 16.44%, 98.63%, and 35.48% of women with PE had increased systolic and normal diastolic blood pressure (SBP and DBP) values, proteinuria, edema, and overweight (BMI≥25), respectively. In the control group, 100%, 1.53%, 1.12%, and 35.48% of cases had normal SBP values with no proteinuria, DBP>90 mm Hg, edema, and overweight (BMI≥25), respectively. An association was observed between the CC genotype of the rs8068318 polymorphism of the

Indexed as

Pre-EclampsiaAdultFemaleHumansOverweightPregnancyReceptors, ProgesteroneT-Box Domain ProteinsTranscription FactorsYoung AdultReceptors, ProgesteroneT-Box Domain Protein 2T-Box Domain ProteinsTranscription FactorsEdemaPolymorphic locusPreeclampsiaProteinuriars1042838 PGRrs8068318TBX2

Identifiers

PMID35891763

DOI10.22092/ARI.2021.356481.1852

PMCPMC9288621

OpenAlexW4288212881

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.