ReviewViruses2022
Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field.
Aurelio Bonavia, Samuel R Dominguez, Gabriela Dveksler, Sara Gagneten, Megan Howard, Scott Jeffers, Zhaohui Qian, Mary Kathryn Smith, Larissa B Thackray, Dina B Tresnan and 4 more
Open access · goldAbstract readBiographyHistorical ArticleReview
In one paragraphReview in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors at 13 institutions in 3 countries.
Aurelio BonaviaVaccine Development, Bill & Melinda Gates Medical Research Institute, Cambridge, MA 02139, USA.
Samuel R DominguezDepartment of Pediatrics-Infectious Diseases, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Gabriela DvekslerDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0003-3037-1155 Sara GagnetenDivision of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA.
Scott JeffersGenSight Biologics, 75012 Paris, France.
Zhaohui QianInstitute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100050, China.
Mary Kathryn SmithGeneral Dynamics Information Technology, Falls Church, VA 22030, USA.
Larissa B ThackrayDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Dina B TresnanSafety Surveillance and Risk Management, Worldwide Safety, Pfizer, Groton, CT 06340, USA.
David E WentworthCOVID-19 Emergency Response, Virology Surveillance and Diagnosis Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30329-4027, USA.ORCID 0000-0002-5190-980X Richard K WilliamsNIAID, NIH, Bethesda, MD 20817, USA.
Tanya A MiuraDepartment of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.
Battelle · USCenter for Biologics Evaluation and Research · USCenters for Disease Control and Prevention · USChinese Academy of Medical Sciences & Peking Union Medical College · CNDavidson College · USGates Foundation · USGeneral Dynamics (United States) · USGenSight Biologics (France) · FRPfizer (United States) · USUniformed Services University of the Health Sciences · USUniversity of Colorado Denver · USUniversity of Idaho · USWashington University in St. Louis · US
Funding
Interaction of Galectin-9 and Pregnancy-Specific Glycoprotein 1 in the Regulation of Cells of the Innate and Adaptive Immune SystemR21AI156058 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI DVEKSLER, GABRIELA S · 2021 to 2022
$419kNIAID NIH HHS R21 AI156058
6 · The paper itselfAbstract
Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background knowledge on coronaviruses developed over decades by researchers, including Kathryn (Kay) Holmes. Kay's research team discovered the first coronavirus receptors for mouse hepatitis virus and human coronavirus 229E and contributed a wealth of information on coronaviral spike glycoproteins and receptor interactions that are critical determinants of host and tissue specificity. She collaborated with several research laboratories to contribute knowledge in additional areas, including coronaviral pathogenesis, epidemiology, and evolution. Throughout her career, Kay was an extremely dedicated and thoughtful mentor to numerous graduate students and post-doctoral fellows. This article provides a review of her contributions to the coronavirus field and her exemplary mentoring.
Indexed as
Coronavirus 229E, HumanReceptors, CoronavirusAnimalsCOVID-19History, 21st CenturyHumansMicePandemicsSpike Glycoprotein, CoronavirusReceptors, CoronavirusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2coronaviruscoronavirus receptorscoronavirus spike glycoprotein
Identifiers
PMID35891553
PMCPMC9315735
OpenAlexW4286462563
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390