Evidence map›Paper›PMID 35891536›Full record

ArticleViruses2022

Phosphomimetic S207D Lysyl-tRNA Synthetase Binds HIV-1 5'UTR in an Open Conformation and Increases RNA Dynamics.

William A Cantara, Chathuri Pathirage, Joshua Hatterschide, Erik D Olson, Karin Musier-Forsyth

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Structural basis for aminoacylation of cellular modified tRNAbioRxiv : the preprint server for biology · 2024
    Article
  3. Article
  4. Review
  5. Sequestering the 5'-cap for viral RNA packaging.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

William A CantaraDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-3214-7635
Chathuri PathirageDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-1527-0882
Joshua HatterschideDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Erik D OlsonDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Karin Musier-ForsythDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
The Ohio State University · US

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
X-ray Crystallographic Fragment Screening CoreU54AI150472 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI GRIFFIN, PATRICK ROBERT · 2019 to 2021
$15.7M
Cellular Factors Critical for Initiation of HIV-1 Reverse TranscriptaseR01AI150493 · NIAID · OHIO STATE UNIVERSITY · PI MUSIER-FORSYTH, KARIN M · 2020 to 2022
$1.2M
A Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998k
NIAID NIH HHS R01 AI150493NIGMS NIH HHS P30 GM124169NIH HHS RO1 AI150493NIH HHS S10 OD018483NIH HHS U54 AI150472
6 · The paper itself

Abstract

Interactions between lysyl-tRNA synthetase (LysRS) and HIV-1 Gag facilitate selective packaging of the HIV-1 reverse transcription primer, tRNA

Indexed as

HIV-1HIV SeropositivityLysine-tRNA Ligase5' Untranslated RegionsHumansNucleic Acid ConformationRNA, TransferRNA, Viral5' Untranslated RegionsLysine-tRNA LigaseRNA, TransferRNA, Viral5′ untranslated regionhuman immunodeficiency virus type 1lysyl–tRNA synthetaseRNA dynamicsRNA structureselective 2′-hydroxyl acylation analyzed by primer extensionsmall-angle X-ray scatteringtRNA-like elementtRNALys3 primerviral RNA

Identifiers

PMID35891536
PMCPMC9315659
OpenAlexW4285732513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.