Evidence map›Paper›PMID 35891473›Full record

ArticleViruses2022

Comparative Dynamics of Delta and Omicron SARS-CoV-2 Variants across and between California and Mexico.

Sanjay R Mehta, Davey M Smith, Celia Boukadida, Antoine Chaillon

Abstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Tracing SARS-CoV-2 clusters across local scales using genomic data.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sanjay R MehtaDepartment of Medicine, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-2028-8158
Davey M SmithDepartment of Medicine, University of California, San Diego, CA 92093, USA.
Celia BoukadidaCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México 14080, Mexico.ORCID 0000-0002-1744-0083
Antoine ChaillonDepartment of Medicine, University of California, San Diego, CA 92093, USA.ORCID 0000-0001-9490-3857

Funding

Primary Infection Resource Consortium (PIRC)R24AI106039 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2013 to 2021
$23.1M
Ethno-epidemiology of HCV, HIV and Overdose associated with Drug Marketsand Drug TourismR01DA049644 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STRATHDEE, STEFFANIE A. · 2020 to 2024
$8.2M
Integrating HCV services into HIV programs for PWID in IndiaR01AI145555 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H, SOLOMON, SUNIL SUHAS · 2019 to 2024
$6.2M
Risks, Benefits, and Stakeholder Perspectives of Molecular Epidemiology for HIV Prevention (HIV-ME)R01MH124590 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET, SUGARMAN, JEREMY · 2020 to 2024
$3.9M
Brain Myeloid Cells are Sources of HIV-associated Damage and Viral DispersalR01DA055491 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHAILLON, ANTOINE · 2021 to 2025
$3.6M
Automation and Evaluation of Real-Time Transmission Network-Based HIV Prevention Services in New York CityR01AI135992 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WERTHEIM, JOEL OKRENT · 2018 to 2022
$3.6M
The HIV-associated Opioid Micro-Environment (HOME) ProjectDP2DA051915 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GIANELLA WEIBEL, SARA · 2020 to 2020
$2.4M
Mentoring Translational Research in HIVK24AI100665 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2021
$1.5M
NIAID NIH HHS K24 AI100665NIAID NIH HHS R01 AI135992NIAID NIH HHS R01 AI145555NIAID NIH HHS R24 AI106039NIDA NIH HHS DP2 DA051915NIDA NIH HHS R01 DA049644NIDA NIH HHS R01 DA055491NIH HHS AI306214 and AI100665NIH HHS DA049644, AI145555, MH128153 (R01), AI106039 AI106039, MH124590, AI135992, DA049644and DP2 CA051915NIMH NIH HHS R01 MH124590
6 · The paper itself

Abstract

Evolutionary analysis using viral sequence data can elucidate the epidemiology of transmission. Using publicly available SARS-CoV-2 sequence and epidemiological data, we developed discrete phylogeographic models to interrogate the emergence and dispersal of the Delta and Omicron variants in 2021 between and across California and Mexico. External introductions of Delta and Omicron in the region peaked in early July (2021-07-10 [95% CI: 2021-04-20, 2021-11-01]) and mid-December (2021-12-15 [95% CI: 2021-11-14, 2022-01-09]), respectively, 3 months and 2 weeks after first detection. These repeated introductions coincided with domestic migration events with no evidence of a unique transmission hub. The spread of Omicron was most consistent with gravity centric patterns within Mexico. While cross-border events accounted for only 5.1% [95% CI: 4.3-6] of all Delta migration events, they accounted for 20.6% [95% CI: 12.4-29] of Omicron movements, paralleling the increase in international travel observed in late 2021. Our investigations of the Delta and Omicron epidemics in the California/Mexico region illustrate the complex interplay and the multiplicity of viral and structural factors that need to be considered to limit viral spread, even as vaccination is reducing disease burden. Understanding viral transmission patterns may help intra-governmental responses to viral epidemics.

Indexed as

COVID-19SARS-CoV-2CaliforniaHumansMexicoPhylogeographyCOVID-19DeltaOmicronphylogeographySARS-CoV-2variants

Identifiers

PMID35891473
PMCPMC9317407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.