ArticleViruses2022
A Deeper Insight into Evolutionary Patterns and Phylogenetic History of ORF Virus through the Whole Genome Sequencing of the First Italian Strains.
Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Host-Orf virus interactions: A comprehensive review of pathogenesis and immune evasion mechanisms.Virulence · 2026Review
- First identification of orf virus from an outbreak of contagious ecthyma in Polish sheep.Journal of veterinary research · 2026Article
- Unravelling the Evolutionary Complexity of Orf Virus: A Global and Multi-Host Perspective.Viruses · 2026Article
- The whole genome analysis of four Orf virus strains from Europe and South America.Virus evolution · 2026Article
- Synergistic Effect of Maternal Micronutrient Supplementation on ORFV DNA Vaccine Immune Response in a Pregnant Model.Biological trace element research · 2025Article
- Development of attenuated Orf virus as a safe oncolytic viral vector for nasopharyngeal carcinoma treatment.Virology journal · 2025Article
- Article
- Human orf virus (family Poxviridae) infection following a lamb bite in Hungary.Archives of virology · 2024Article
- The Global Evolutionary History of Orf Virus in Sheep and Goats Revealed by Whole Genomes Data.Viruses · 2024Article
- Retrospective research: identifying and conducting phylogenetic analyses on four Orf virus strains isolated in Yunnan province between 2021 and 2023-revealing their significance and characteristic features.Frontiers in veterinary science · 2024Article
- Human Orf with Immune-Mediated Reactions: A Systematic Review.Microorganisms · 2023Review
- Orf virus DNA prime-protein boost strategy is superior to adenovirus-based vaccination in mice and sheep.Frontiers in immunology · 2023Article
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Authors and funding
14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Orf virus (ORFV) is distributed worldwide and is the causative agent of contagious ecthyma that mainly occurs in sheep and goats. This disease was reported for the first time at the end of 18th century in Europe but very little is currently known about the temporal and geographic origins of this virus. In the present study, the use of new Italian whole genomes allowed for better inference on the evolutionary history of ORFV. In accordance with previous studies, two genome types (S and G) were described for infection of sheep and goats, respectively. These two well-differentiated groups of genomes originated for evolutive convergence in the late 1800s in two different areas of the world (Europe for S type and Asia for G type), but it was only in the early 1900s that the effective size of ORFV increased among hosts and the virus spread across the whole European continent. The Italian strains which were sequenced in the present study were isolated on the Mediterranean island of Sardinian and showed to be exclusive to this geographic area. One of them is likely representative of the early European forms of ORFV which infected sheep and became extinct about one century ago. Such an ancient Sardinian strain may have reached the island simple by chance, where it quickly adapted to the new habitat.
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