Evidence map›Paper›PMID 35891343›Full record

ArticleViruses2022

Human Beta Papillomavirus Type 8 E1 and E2 Proteins Suppress the Activation of the RIG-I-Like Receptor MDA5.

Stephanie Rattay, Martin Hufbauer, Christian Hagen, Bastian Putschli, Christoph Coch, Baki Akgül, Gunther Hartmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Targeting innate immunity to overcome immune evasion in HPV-associated cancers.Frontiers in cellular and infection microbiology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stephanie RattayInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Gebäude 12, Venusberg-Campus 1, 53127 Bonn, Germany.ORCID 0000-0002-9341-1911
Martin HufbauerInstitute of Virology, Medical Faculty and University Hospital Cologne, University of Cologne, Fürst-Pückler-Str. 56., 50935 Cologne, Germany.ORCID 0000-0003-4106-0520
Christian HagenInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Gebäude 12, Venusberg-Campus 1, 53127 Bonn, Germany.
Bastian PutschliInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Gebäude 12, Venusberg-Campus 1, 53127 Bonn, Germany.
Christoph CochInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Gebäude 12, Venusberg-Campus 1, 53127 Bonn, Germany.
Baki AkgülInstitute of Virology, Medical Faculty and University Hospital Cologne, University of Cologne, Fürst-Pückler-Str. 56., 50935 Cologne, Germany.ORCID 0000-0002-6564-9412
Gunther HartmannInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Gebäude 12, Venusberg-Campus 1, 53127 Bonn, Germany.
University of Bonn · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent infections of the skin with the human papillomavirus of genus beta (β-HPV) in immunocompetent individuals are asymptomatic, but in immunosuppressed patients, β-HPV infections exhibit much higher viral loads on the skin and are associated with an increased risk of skin cancer. Unlike with HPV16, a high-risk α-HPV, the impact of β-HPV early genes on the innate immune sensing of viral nucleic acids has not been studied. Here, we used primary skin keratinocytes and U2OS cells expressing HPV8 or distinct HPV8 early genes and well-defined ligands of the nucleic-acid-sensing receptors

Indexed as

BetapapillomavirusNucleic AcidsOncogene Proteins, ViralPapillomavirus InfectionsHumansInterferon-Induced Helicase, IFIH1KeratinocytesLeukocytes, MononuclearRNAToll-Like Receptor 3Viral Envelope ProteinsIFIH1 protein, humanInterferon-Induced Helicase, IFIH1Nucleic AcidsOncogene Proteins, ViralRNAToll-Like Receptor 3Viral Envelope Proteinshuman papillomavirus type 8 (HPV8)immune systeminnate immunitynucleic acid detectionpattern recognition receptorsreceptor signalingvirus host interactions

Identifiers

PMID35891343
PMCPMC9317666
OpenAlexW4283397806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.