Evidence map›Paper›PMID 35891311›Full record

ArticleVaccines2022

Immune Correlates of Disseminated BCG Infection in IL12RB1-Deficient Mice.

Xuyang Wang, Liqiu Jia, Yang Liu, Jing Wang, Chao Qiu, Tao Li, Wenhong Zhang, Zhaoqin Zhu, Jing Wu, Yanmin Wan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xuyang WangNational Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Department of Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Liqiu JiaNational Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Department of Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Yang LiuShanghai Public Health Clinical Center, Department of Laboratory Medicine, Shanghai 201508, China.
Jing WangShanghai Public Health Clinical Center, Department of Laboratory Medicine, Shanghai 201508, China.
Chao QiuKey Laboratory of Medical Molecular Virology (MOE/MOH), Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Tao LiShanghai Public Health Clinical Center, Department of Tuberculosis, Shanghai 201508, China.
Wenhong ZhangNational Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Department of Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Zhaoqin ZhuShanghai Public Health Clinical Center, Department of Laboratory Medicine, Shanghai 201508, China.
Jing WuNational Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Department of Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.ORCID 0000-0002-1224-0912
Yanmin WanNational Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Department of Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.ORCID 0000-0001-5027-9423
Fudan University · CNShanghai Public Health Clinical Center · CNShanghai Medical College of Fudan University · CN

Funding

Key Discipline Construction Plan from Shanghai Municipal Health Commission GWV-10.1-XK01National Natural Science Foundation of China 81671636National Natural Science Foundation of China 81700014National Natural Science Foundation of China 81971559Shanghai Municipal Science and Technology Major Project HS2021SHZX001the Shanghai Science and Technology Committee 20dz2260100the Shanghai Science and Technology Committee 20Z11901100
6 · The paper itself

Abstract

Interleukin-12 receptor β1 (IL12RB1)-deficient individuals show increased susceptibilities to local or disseminated BCG infection and environmental mycobacteria infection. However, the low clinical penetrance of IL12RB1 deficiency and low recurrence rate of mycobacteria infection suggest that protective immunity still exists in this population. In this study, we investigated the mechanism of tuberculosis suppression using the IL12RB1-deficient mouse model. Our results manifested that

Indexed as

adaptive immunityBCGIFN-γIL12RB1innate immunityMSMD

Identifiers

PMID35891311
PMCPMC9316795
OpenAlexW4285794779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.