Evidence map›Paper›PMID 35891299›Full record

ArticleVaccines2022

Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis.

Eli Magen, Sumit Mukherjee, Mahua Bhattacharya, Rajesh Detroja, Eugene Merzon, Idan Blum, Alejandro Livoff, Mark Shlapobersky, Gideon Baum, Ran Talisman and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. mRNA: Vaccine or Gene Therapy? The Safety Regulatory Issues.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Eli MagenMedicine C Department, Clinical Immunology and Allergy Division, Barzilai University Medical Center, Ben-Gurion University of the Negev, Ashkelon 7830604, Israel.ORCID 0000-0002-7713-423X
Sumit MukherjeeAzrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.ORCID 0000-0001-9807-7994
Mahua BhattacharyaAzrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.ORCID 0000-0002-5114-5678
Rajesh DetrojaAzrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.ORCID 0000-0003-2617-6998
Eugene MerzonLeumit Health Services, Tel Aviv 6473817, Israel.
Idan BlumMedicine C Department, Clinical Immunology and Allergy Division, Barzilai University Medical Center, Ben-Gurion University of the Negev, Ashkelon 7830604, Israel.
Alejandro LivoffPathology Department, Barzilai University Medical Center, Ashkelon 7830604, Israel.
Mark ShlapoberskyPathology Department, Barzilai University Medical Center, Ashkelon 7830604, Israel.ORCID 0000-0002-4819-935X
Gideon BaumAzrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.
Ran TalismanPlastic Surgery Department, Barzilai University Medical Center, Ashkelon 7830604, Israel.
Evgenia CherniavskyImaging Department, Barzilai University Medical Center, Ashkelon 7830604, Israel.
Amir DoriDepartment of Neurology, Sheba Medical Center, Ramat Gan 5262000, Israel.ORCID 0000-0003-4633-1481
Milana Frenkel-MorgensternAzrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.ORCID 0000-0002-0329-4599
Bar-Ilan University · ILBarzilai Medical Center · ILBen-Gurion University of the Negev · ILTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here, we report a rare case of myositis after injection of the first dose of BNT162b2 COVID-19 mRNA vaccine into the left deltoid muscle of a 34-year-old, previously healthy woman who presented progressive proximal muscle weakness, progressive dysphagia, and dyspnea with respiratory failure. One month after vaccination, BNT162b2 vaccine mRNA expression was detected in a tissue biopsy of the right deltoid and quadriceps muscles. We propose this case as a rare example of COVID-19 mRNA vaccine-induced myositis. This study comprehensively characterizes the clinical and molecular features of BNT162b2 mRNA vaccine-associated myositis in which the patient was severely affected.

Indexed as

BNT162b2COVID-19mRNA vaccinemyositis

Identifiers

PMID35891299
PMCPMC9324661
OpenAlexW4285732568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.