Evidence map›Paper›PMID 35891174›Full record

ArticleVaccines2022

Prioritization of Vaccines for Inclusion into China's Expanded Program on Immunization: Evidence from Experts' Knowledge and Opinions.

Chao Ma, Junhong Li, Nan Wang, Yamin Wang, Yudan Song, Xiang Zeng, Canjun Zheng, Zhijie An, Lance Rodewald, Zundong Yin

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  9. Vaccine pricing strategies in China.BMJ global health · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chao MaNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Junhong LiNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.ORCID 0000-0001-8678-0666
Nan WangShanghai Municipal Center for Disease Control and Prevention, Shanghai 201204, China.
Yamin WangNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Yudan SongNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Xiang ZengZhuhai Center for Disease Control and Prevention, Zhuhai 519000, China.
Canjun ZhengDivision of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 100050, China.ORCID 0000-0001-6822-8755
Zhijie AnNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Lance RodewaldNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.ORCID 0000-0003-2593-542X
Zundong YinNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Chinese Center For Disease Control and Prevention · CNShanghai Municipal Center For Disease Control Prevention · CN

Funding

China CDC: The Emergency Response Mechanism Operation Program 131031001000200001
6 · The paper itself

Abstract

backgroundVaccine developers in China have made an increasing number of infectious diseases preventable through vaccination. An appropriate decision-making procedure is necessary for making wise decisions on whether to introduce new vaccines into the Expanded Program on Immunization (EPI). When there are several vaccines that could potentially be considered, a scientifically justifiable mechanism is needed for prioritizing and sequencing vaccines for consideration.

methodsWe used a modified Delphi technique (MDT) to develop and refine an indicator system to prioritize vaccines and make policy recommendations concerning their introduction into China's EPI system. From January through May 2021, thirty-nine experts were recruited and participated in a two-round Delphi survey that was based on a set of candidate indicators obtained through a literature review and reference to the WHO vaccine introduction recommendations. Using the resulting indicator system, we conducted a third consultation with a multi-disciplinary group of experts who scored five program-eligible candidate vaccines to determine prioritization and sequencing for consideration of inclusion into the EPI.

resultsResponse rates of the thirty-nine experts were 100% and 97.4% across the two rounds. Authority coefficients from rounds one to three were over 0.70, reflecting the high accuracy and reliability of the consultation. Coordination coefficients of importance scores for primary, secondary, and tertiary indicators were 0.486, 0.356, 0.275 in round one, and 0.405, 0.340, and 0.236 in round two. According to the scores from 30 experts using our indicator system, the sequence and scores (1-10 scale, 10 highest) of 5 candidate vaccines were varicella (6.91), meningococcal conjugate AC (6.83), Hib (6.74), influenza (6.56), and EV71 (6.17) vaccines.

conclusionsA modified Delphi technique effectively built a scientific, rational, comprehensive, and systematic indicator system for prioritizing vaccine candidates for consideration of inclusion into the EPI. The rank order will be used by the technical working groups of China's National Immunization Advisory Committee to sequentially develop and present Evidence-to-Recommendation tables for making policy recommendations.

Indexed as

DelphiExpanded Program on Immunizationinclusionindicator systemvaccine

Identifiers

PMID35891174
PMCPMC9318118
OpenAlexW4283574070

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.