Evidence map›Paper›PMID 35890706›Full record

ReviewPolymers2022

Applications of Electrospun Drug-Eluting Nanofibers in Wound Healing: Current and Future Perspectives.

Nakamwi Akombaetwa, Alick Bwanga, Pedzisai Anotida Makoni, Bwalya A Witika

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nakamwi AkombaetwaDepartment of Pharmacy, Livingstone Central Hospital, P.O. Box 60091, Livingstone 10101, Zambia.
Alick BwangaDepartment of Surgery, University Teaching Adult Hospital, Private Bag RW 1 X Ridgeway, Lusaka 10101, Zambia.
Pedzisai Anotida MakoniDivision of Pharmacology, Faculty of Pharmacy, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0002-8475-447X
Bwalya A WitikaDepartment of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa.ORCID 0000-0002-4034-9368

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wounds are a consequence of disruption in the structure, integrity, or function of the skin or tissue. Once a wound is formed following mechanical or chemical damage, the process of wound healing is initiated, which involves a series of chemical signaling and cellular mechanisms that lead to regeneration and/or repair. Disruption in the healing process may result in complications; therefore, interventions to accelerate wound healing are essential. In addition to mechanical support provided by sutures and traditional wound dressings, therapeutic agents play a major role in accelerating wound healing. The medicines known to improve the rate and extent of wound healing include antibacterial, anti-inflammatory, and proliferation enhancing agents. Nonetheless, the development of these agents into eluting nanofibers presents the possibility of fabricating wound dressings and sutures that provide mechanical support with the added advantage of local delivery of therapeutic agents to the site of injury. Herein, the process of wound healing, complications of wound healing, and current practices in wound healing acceleration are highlighted. Furthermore, the potential role of drug-eluting nanofibers in wound management is discussed, and lastly, the economic implications of wounds as well as future perspectives in applying fiber electrospinning in the design of wound dressings and sutures are considered and reported.

Indexed as

drug-eluting nanofiberselectrospinningsutureswound dressingwound healing

Identifiers

PMID35890706
PMCPMC9324048

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.