Evidence map›Paper›PMID 35890398›Full record

ArticlePharmaceutics2022

Opening the Blood Brain Barrier with an Electropermanent Magnet System.

Sahar Jafari, Ittai S Baum, Oleg G Udalov, Yichien Lee, Olga Rodriguez, Stanley T Fricke, Maryam Jafari, Mostafa Amini, Roland Probst, Xinyao Tang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Sahar JafariWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USA.
Ittai S BaumWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USA.
Oleg G UdalovWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USA.
Yichien LeeDepartment of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Olga RodriguezDepartment of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Stanley T FrickeDepartment of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Maryam JafariIndependent Consultant, Oklahoma City, OK 73134, USA.
Mostafa AminiDepartment of Management Science and Information Systems, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0002-6515-9835
Roland ProbstACUITYnano LLC, Chevy Chase, MD 20815, USA.ORCID 0000-0002-2975-1081
Xinyao TangWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USA.
Cheng ChenWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USA.
David J AriandoDepartment of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA.
Anjana HevaganingeWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USA.
Lamar O MairWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USA.ORCID 0000-0001-9459-3932
Christopher AlbaneseDepartment of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Irving N WeinbergWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USA.ORCID 0000-0001-8564-2982
Weinberg Medical Physics (United States) · USGeorgetown University · USOklahoma State University · USUniversity of Florida · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
Non-invasive efficient brain delivery of Prussian Blue for treatment of Alzheimer diseaseR44AG066386 · NIA · WEINBERG MEDICAL PHYSICS, LLC · PI WEINBERG, IRVING · 2019 to 2021
$2.1M
Preclinical Imaging - Bruker 70/30USR BioSpec MagnetS10OD025153 · OD · GEORGETOWN UNIVERSITY · PI ALBANESE, CHRISTOPHER · 2019 to 2019
$1.9M
NIA NIH HHS R44 AG066386NIH HHS P30 CA051008NIH HHS R44AG066386NIH HHS S10 OD025153
6 · The paper itself

Abstract

Opening the blood brain barrier (BBB) under imaging guidance may be useful for the treatment of many brain disorders. Rapidly applied magnetic fields have the potential to generate electric fields in brain tissue that, if properly timed, may enable safe and effective BBB opening. By tuning magnetic pulses generated by a novel electropermanent magnet (EPM) array, we demonstrate the opening of tight junctions in a BBB model culture in vitro, and show that induced monophasic electrical pulses are more effective than biphasic ones. We confirmed, with in vivo contrast-enhanced MRI, that the BBB can be opened with monophasic pulses. As electropermanent magnets have demonstrated efficacy at tuning B0 fields for magnetic resonance imaging studies, our results suggest the possibility of implementing an EPM-based hybrid theragnostic device that could both image the brain and enhance drug transport across the BBB in a single sitting.

Indexed as

blood brain barrierelectropermanent magnetmagnetic resonance imaging

Identifiers

PMID35890398
PMCPMC9317373
OpenAlexW4286504515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.