Evidence map›Paper›PMID 35890360›Full record

ArticlePharmaceutics2022

Chalcones as Anti-Glioblastoma Stem Cell Agent Alone or as Nanoparticle Formulation Using Carbon Dots as Nanocarrier.

Eduardo A Veliz, Anastasiia Kaplina, Sajini D Hettiarachchi, Athina L Yoham, Carolina Matta, Sabrin Safar, Meghana Sankaran, Esther L Abadi, Emel Kirbas Cilingir, Frederic A Vallejo and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Eduardo A VelizDepartment of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA.
Anastasiia KaplinaDepartment of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA.
Sajini D HettiarachchiDepartment of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA.ORCID 0000-0002-4063-1355
Athina L YohamDepartment of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA.
Carolina MattaDepartment of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA.
Sabrin SafarDepartment of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA.
Meghana SankaranDepartment of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA.
Esther L AbadiDepartment of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA.
Emel Kirbas CilingirDepartment of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA.
Frederic A VallejoDepartment of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA.
Winston M WaltersDepartment of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA.
Steven VanniDepartment of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA.
Roger M LeblancDepartment of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, USA.
Regina M GrahamDepartment of Neurosurgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA.ORCID 0000-0003-0103-2971
University of Miami · US

Funding

BCURED Foundation n/aFlorida Department of Health 21L08Mystic Force Foundation n/a
6 · The paper itself

Abstract

The current prognosis for glioblastoma is dismal. Treatment-resistant glioblastoma stem cells (GSCs) and the failure of most drugs to reach therapeutic levels within the tumor remain formidable obstacles to successful treatment. Chalcones are aromatic ketones demonstrated to reduce malignant properties in cancers including glioblastoma. Nanomedicines can increase drug accumulation and tumor cell death. Carbon-dots are promising nanocarriers that can be easily functionalized with tumor-targeting ligands and anti-cancer drugs. Therefore, we synthesized a series of 4'-amino chalcones with the rationale that the amino group would serve as a "handle" to facilitate covalent attachment to carbon-dots and tested their cytotoxicity toward GSCs. We generated 31 chalcones (22 4'-amino and 9 4' derivatives) including 5 novel chalcones, and found that 13 had an IC

Indexed as

carbon dotchalconedrug delivery systemglioblastomaglioblastoma stem cellGSCnanocarrier

Identifiers

PMID35890360
PMCPMC9316063
OpenAlexW4285597249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.