Evidence map›Paper›PMID 35890311›Full record

ArticlePharmaceutics2022

Schistosome Sulfotransferases: Mode of Action, Expression and Localization.

Meghan A Guzman, Anastasia Rugel, Sevan N Alwan, Reid Tarpley, Alexander B Taylor, Frédéric D Chevalier, George R Wendt, James J Collins, Timothy J C Anderson, Stanton F McHardy and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Computer-Assisted Discovery ofBioinformatics and biology insights · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Meghan A GuzmanDepartment of Microbiology and Immunology, University of Texas Health, San Antonio, TX 78229, USA.
Anastasia RugelDepartment of Microbiology and Immunology, University of Texas Health, San Antonio, TX 78229, USA.
Sevan N AlwanDepartment of Biochemistry and Structural Biology, University of Texas Health, San Antonio, TX 78229, USA.ORCID 0000-0001-8701-4859
Reid TarpleyCenter for Innovative Drug Discovery, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Alexander B TaylorDepartment of Biochemistry and Structural Biology, University of Texas Health, San Antonio, TX 78229, USA.ORCID 0000-0003-3517-6033
Frédéric D ChevalierHost Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0003-2611-8106
George R WendtDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
James J CollinsDepartment of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Timothy J C AndersonDisease Intervention & Prevention, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Stanton F McHardyCenter for Innovative Drug Discovery, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Philip T LoVerdeDepartment of Biochemistry and Structural Biology, University of Texas Health, San Antonio, TX 78229, USA.
The University of Texas Health Science Center at San Antonio · USSouthwestern Medical Center · USTexas Biomedical Research Institute · USThe University of Texas at San Antonio · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
San Antonio Biomedical Education and ResearchK12GM111726 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LECHLEITER, JAMES D, OYAJOBI, BABATUNDE OLUKAYODE · 2015 to 2024
$7.6M
Structure-guided redesign of an antischistosomal drugR01AI115691 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LOVERDE, PHILIP T · 2015 to 2019
$2.6M
NCI NIH HHS P30 CA054174NIAID NIH HHS R01 AI115691NIGMS NIH HHS 2K12 GM111726NIGMS NIH HHS K12 GM111726
6 · The paper itself

Abstract

Oxamniquine (OXA) is a prodrug activated by a sulfotransferase (

Indexed as

mechanism of killingoxamniquine derivativesSchistosoma mansonischistosomiasisS. haematobiumS. japonicumwhole worm in situ hybridization

Identifiers

PMID35890311
PMCPMC9323829
OpenAlexW4283828178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.