Evidence map›Paper›PMID 35890247›Full record

ArticlePharmaceutics2022

Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies.

Chih Kit Chung, Uwe Beekmann, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis J Cruz

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  4. Review
  5. Production of Bacterial Exopolysaccharides: Xanthan and Bacterial Cellulose.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chih Kit ChungDepartment of Radiology, Division Translational Nanobiomaterials and Imaging, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Uwe BeekmannJeNaCell GmbH, Göschwitzer Straße 22, 07745 Jena, Germany.ORCID 0000-0002-9839-5527
Dana KralischJeNaCell GmbH, Göschwitzer Straße 22, 07745 Jena, Germany.
Katja BierauPilotality, Eerbeeklaan 42, 2573 HT Gravenhage, The Netherlands.
Alan ChanPercuros B.V., Zernikedreef 8, 2333 CL Leiden, The Netherlands.
Ferry OssendorpDepartment of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Luis J CruzDepartment of Radiology, Division Translational Nanobiomaterials and Imaging, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Leiden University Medical Center · NLPercuros (Netherlands) · NL

Funding

European Commission 675743European Commission 734684European Commission 777682European Commission 807281European Commission 852985European Commission 872391European Commission 872860European Commission 952520NWO 723.012.110 L.J.C
6 · The paper itself

Abstract

Immune checkpoint blocking therapy is a promising cancer treatment modality, though it has limitations such as systemic toxicity, which can often be traced to uncontrolled antibody spread. Controlling antibody release with delivery systems is, therefore, an attractive approach to reduce systemic antibody spread and potentially mitigate the side effects of checkpoint immunotherapy. Here, bacterial cellulose (BC) was produced and investigated as a delivery system for optimizing checkpoint-blocking antibody delivery. BC was produced in 24-well plates, and afterward, the edges were removed to obtain square-shaped BC samples with a surface of ~49 mm

Indexed as

bacterial cellulosecancer immunotherapycheckpoint blocking therapydrug delivery systemside effectssustained release

Identifiers

PMID35890247
PMCPMC9316226
OpenAlexW4283579279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.