Evidence map›Paper›PMID 35889815›Full record

ReviewNutrients2022

Refeeding Syndrome: A Critical Reality in Patients with Chronic Disease.

Gabija Krutkyte, Leyla Wenk, Jonas Odermatt, Philipp Schuetz, Zeno Stanga, Natalie Friedli

Abstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Australasian Society of Parenteral and Enteral Nutrition: Consensus statements on refeeding syndrome.Nutrition & dietetics : the journal of the Dietitians Association of Australia · 2025
    Guideline
  2. Article
  3. Article
  4. Incidence and risk factors of refeeding syndrome in inpatients undergoing enteral and parenteral nutrition hospitalized in a university medical hospital.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Observational
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabija KrutkyteDivision of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Leyla WenkDivision of Paediatric Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.
Jonas OdermattDivision of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Philipp SchuetzDivision of General Internal and Emergency Medicine, Medical University Department, Kantonsspital Aarau, 5001 Aarau, and Medical Faculty, University of Basel, 4056 Basel, Switzerland.
Zeno StangaDivision of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Natalie FriedliMedical Department, Hospital of Thun, 3600 Thun, Switzerland.

Funding

University Hospital of Bern WFE-002
6 · The paper itself

Abstract

Malnutrition is one of the most frequent metabolic challenges in the population of chronically ill patients. This results in increased administration of nutritional therapy in inpatient settings, which poses the risk of side effects, in particular, the development of refeeding syndrome. If not managed accordingly, it leads to a significant rise in morbidity and mortality. However, despite its importance, evidence-based recommendations on the management of refeeding syndrome are largely lacking, and only a few randomized controlled trials have been conducted. In light of this, the aim of this review is to raise awareness of refeeding syndrome in chronically ill patients by critically reviewing recent literature and providing a short overview as well as diagnosis and treatment algorithms of this underreported metabolic condition. In summary, recent findings suggest undergoing risk assessment and stratification for every patient receiving nutritional therapy. According to this, adaptation of energy and fluid support during the replenishment phase should be implemented in the nutritional therapy for patients at high risk. Additionally, continuous monitoring should take place, and appropriate actions should be initiated when necessary.

Indexed as

MalnutritionRefeeding SyndromeChronic DiseaseHumansNutritional SupportRisk Assessmentcatabolismmalnutritionnutritional supportrefeeding syndrome

Identifiers

PMID35889815
PMCPMC9324596

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.