Evidence map›Paper›PMID 35889746›Full record

Trial reportNutrients2022

Metagenomic Changes of Gut Microbiota following Treatment of

Maria Pina Dore, Rosangela Sau, Caterina Niolu, Marcello Abbondio, Alessandro Tanca, Stefano Bibbò, Mariafrancesca Loria, Giovanni Mario Pes, Sergio Uzzau

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Beyond Antibiotics: Alternative Strategies TargetingExpert reviews in molecular medicine · 2026
    Review
  4. Review
  5. Review
  6. Nutrients · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maria Pina DoreDipartimento di Medicina, Chirurgia e Farmacia, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.ORCID 0000-0001-7305-3531
Rosangela SauDipartimento di Scienze Biomediche, University of Sassari, Viale San Pietro 43B, 07100 Sassari, Italy.ORCID 0000-0001-6997-4688
Caterina NioluDipartimento di Medicina, Chirurgia e Farmacia, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.
Marcello AbbondioDipartimento di Scienze Biomediche, University of Sassari, Viale San Pietro 43B, 07100 Sassari, Italy.ORCID 0000-0003-2126-4817
Alessandro TancaDipartimento di Scienze Biomediche, University of Sassari, Viale San Pietro 43B, 07100 Sassari, Italy.ORCID 0000-0002-6066-7048
Stefano BibbòCEMAD Digestive Disease Center-Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0002-8043-4807
Mariafrancesca LoriaDipartimento di Medicina, Chirurgia e Farmacia, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.
Giovanni Mario PesDipartimento di Medicina, Chirurgia e Farmacia, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.ORCID 0000-0003-3265-2823
Sergio UzzauDipartimento di Scienze Biomediche, University of Sassari, Viale San Pietro 43B, 07100 Sassari, Italy.ORCID 0000-0001-6246-2794
University of Sassari · ITAgostino Gemelli University Polyclinic · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProbiotic supplementation to antibiotic regimens against

aimsTo evaluate microbiota modifications due to a low-dose quadruple therapy with bismuth or

methodsForty-six patients infected with

resultsEradication rate was by ITT 78% in both groups, and by PP analysis 85.7% and 95.5% for Gastrus

conclusionsLow-dose bismuth quadruple therapy proved to be effective with lower costs and amount of antibiotics and bismuth. Gastrus

Indexed as

Gastrointestinal MicrobiomeHelicobacter InfectionsHelicobacter pyloriLimosilactobacillus reuteriAnti-Bacterial AgentsBismuthDrug Therapy, CombinationHumansMetronidazoleProton Pump InhibitorsRabeprazoleRNA, Ribosomal, 16STetracyclineTreatment OutcomeAnti-Bacterial AgentsBismuthMetronidazoleProton Pump InhibitorsRabeprazoleRNA, Ribosomal, 16STetracycline16S rRNA gene sequencinghuman gut microbiotaprobioticsrandomized clinical trial

Identifiers

PMID35889746
PMCPMC9316840
OpenAlexW4283837367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.