Evidence map›Paper›PMID 35889701›Full record

ArticleNanomaterials (Basel, Switzerland)2022

Development of Lateral Flow Immunochromatographic Test for Rapid Detection of SARS-CoV-2 Virus Antigens in Clinical Specimens.

Rafik Hamed Sayed, Mohamed Samy Abousenna, Shaimaa Abdelall Elsaady, Rafik Soliman, Mohamed Ahmed Saad

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Rafik Hamed SayedCentral Laboratory for Evaluation of Veterinary Biologics, Agricultural Research Center, P.O. Box 131, Cairo 11381, Egypt.ORCID 0000-0002-6320-2537
Mohamed Samy AbousennaCentral Laboratory for Evaluation of Veterinary Biologics, Agricultural Research Center, P.O. Box 131, Cairo 11381, Egypt.ORCID 0000-0003-2202-9544
Shaimaa Abdelall ElsaadyCentral Laboratory for Evaluation of Veterinary Biologics, Agricultural Research Center, P.O. Box 131, Cairo 11381, Egypt.
Rafik SolimanDepartment of Microbiology, Faculty of Veterinary medicine, Cairo University, Giza 12211, Egypt.
Mohamed Ahmed SaadVeterinary Serum and Vaccine Research Institute, Agricultural Research Center, P.O. Box 131, Cairo 11381, Egypt.
Central Laboratory For Agricultural Expert Systems · EGCairo University · EGVeterinary Serum and Vaccine Research Institute · EG

Funding

Science, Technology & Innovation Funding Authority (STDF) under grant COVID 19" call 2 (2021 44423
6 · The paper itself

Abstract

In the presented study, we developed a nanogold lateral glow immunoassay-based technique (LFI-COVID-19 antigen test) for the detection of SARS-CoV-2 nucleocapsid proteins; the developed LFI-COVID-19 Ag test has been tested for limit of detection (LOD), cross-reactivity and interfering substances, and performance. It was found that the performance of the developed LFI-COVID-19 antigen test when it was evaluated by RT-qPCR indicated 95, 98, and 97% for sensitivity, specificity and accuracy, respectively. This complies with the WHO guidelines. It was concluded that the developed LFI-COVID-19 antigen test is a point of care and an alternative approach to current laboratory methods, especially RT-qPCR. It provides an easy, rapid (within 20 min), and on-site diagnostic tool for COVID-19 infection, and it is a cheap test if it is manufactured on a large scale for commercial use.

Indexed as

antigen testingCOVID-19diagnostic testinggold nanoparticlesimmuno-chromatographiclateral flow assaySARS-CoV-2sensitivity and specificity

Identifiers

PMID35889701
PMCPMC9322925
OpenAlexW4286212739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.