ArticleMolecules (Basel, Switzerland)2022
Three New Stigmatellin Derivatives Reveal Biosynthetic Insights of Its Side Chain Decoration.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Natural variation in antimicrobial activity and composition of the secreted metabolomes of the model moss Ceratodon purpureus.Scientific reports · 2026Article
- Anticancer Compounds from Myxobacteria: Current Scenario and Future Perspectives.Anti-cancer agents in medicinal chemistry · 2026Review
- Tentative Identification of Phytochemicals fromPlants (Basel, Switzerland) · 2022Article
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4 authors at 1 institution in 1 country.
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Abstract
Myxobacteria generate natural products with unique chemical structures, which not only feature remarkable biological functions, but also demonstrate unprecedented biosynthetic assembly strategies. The stigmatellins have been previously described as potent inhibitors of the mitochondrial and photosynthetic respiratory chain and originate from an unusual polyketide synthase assembly line. While previous biosynthetic investigations were focused on the formation of the 5,7-dimethoxy-8-hydroxychromone ring, side chain decoration of the hydrophobic alkenyl chain in position 2 was investigated less thoroughly. We report here the full structure elucidation, as well as cytotoxic and antimicrobial activities of three new stigmatellins isolated from the myxobacterium
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