Evidence map›Paper›PMID 35889524›Full record

ArticleMolecules (Basel, Switzerland)2022

Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches.

Ghulam Md Ashraf, Debarati DasGupta, Mohammad Zubair Alam, Saleh S Baeesa, Badrah S Alghamdi, Firoz Anwar, Thamer M A Alqurashi, Sharaf E Sharaf, Waleed Al Abdulmonem, Mohammed A Alyousef and 2 more

Erratum issuedOpen access · goldFull text read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Molecules (Basel, Switzerland) · 2023
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Ghulam Md AshrafDepartment of Medical Laboratory Sciences, College of Health Sciences, and Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab EmiratesORCID 0000-0002-9820-2078
Debarati DasGuptaCollege of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109, USA
Mohammad Zubair AlamPre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Saleh S BaeesaDivision of Neurosurgery, College of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaORCID 0000-0002-3053-7912
Badrah S AlghamdiPre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaORCID 0000-0002-9411-3609
Firoz AnwarDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Thamer M A AlqurashiDepartment of Pharmacology, Faculty of Medicine, King Abdul-Aziz University, Rabigh 21589, Saudi Arabia
Sharaf E SharafPharmaceutical Chemistry Department, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia
Waleed Al AbdulmonemDepartment of Pathology, College of Medicine, Qassim University, P.O. Box 6655, Buraydah 51452, Saudi ArabiaORCID 0000-0003-2984-9262
Mohammed A AlyousefDivision of Neurosurgery, College of Medicine, King Abdulaziz University Hospital, Jeddah 21589, Saudi ArabiaORCID 0000-0002-5216-2277
Fahad A AlhumaydhiDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi ArabiaORCID 0000-0002-0151-8309
Anas ShamsiCentre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman P.O. Box 346, United Arab EmiratesORCID 0000-0001-7055-7056
King Abdulaziz University · SAQassim University · SAAjman University · AEKing Abdul Aziz University Hospital · SAUmm al-Qura University · SAUniversity of Michigan · US

Funding

King Abdulaziz University IFPRC-196-141-2020
6 · The paper itself

Abstract

Microtubule affinity regulating kinase 4 (MARK4) regulates the mechanism of microtubules by its ability to phosphorylate the microtubule-associated proteins (MAP's). MARK4 is known for its major role in tau phosphorylation via phosphorylating Ser

Indexed as

Alzheimer DiseaseDiabetes Mellitus, Type 2MetforminHumansHypoglycemic AgentsMicrotubulesMolecular Docking SimulationProtein BindingProtein Serine-Threonine KinasesHypoglycemic AgentsMetforminProtein Serine-Threonine KinasesAlzheimer’s diseasedrug discoverydrug repurposingMARK4MD simulationmolecular dockingtype 2 diabetes mellitusvirtual screening

Identifiers

PMID35889524
PMCPMC9320910
OpenAlexW4286433276

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.