ArticleMolecules (Basel, Switzerland)2022
Optimisation of Glycerol and Itaconic Anhydride Polycondensation.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Synthesis and Characterization of Bioactive Oligoitaconates with Amino Acid Functional Groups for Tissue Engineering.International journal of molecular sciences · 2025Article
- Article
- Recent progress of poly(glycerol adipate)-based network materials toward tissue engineering applications.Frontiers in bioengineering and biotechnology · 2024Review
- Poly(glycerol itaconate) Crosslinking via the aza-Michael Reaction-A Preliminary Research.Materials (Basel, Switzerland) · 2023Article
- From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications.Gels (Basel, Switzerland) · 2023Article
- Optimization of the Poly(glycerol citraconate) Synthesis Using the Box-Behnken Design.ACS omega · 2023Article
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Authors and funding
4 authors.
Funding
Abstract
Glycerol polyesters have recently become objects of interest in tissue engineering. Barely known so far is poly(glycerol itaconate) (PGItc), a biocompatible, biodegradable polyester. Due to the presence of a C=C electron-acceptor moiety, it is possible to post-modify the product by Michael additions to change the properties of PGItc. Thus, using PGItc as one of the elements of cellular scaffold crosslinked in situ for bone tissue regeneration seems to be a very attractive yet unexplored solution. This work aims to optimize the synthesis of PGItc to obtain derivatives with a double bond in the side chain with the highest conversion rates. The experiments were performed with itaconic anhydride and glycerol using mathematical planning of experiments according to the Box-Behnken plan without solvent and catalyst. The input variables of the process were the ratio of the OH/COOH, temperature, and reaction time. The optimised output variables were: the degree of esterification (ED
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Registered trials
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