Evidence map›Paper›PMID 35889484›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis of 3-Aryl-3-(Furan-2-yl)Propanoic Acid Derivatives, and Study of Their Antimicrobial Activity.

Mikhail V Kalyaev, Dmitry S Ryabukhin, Marina A Borisova, Alexander Yu Ivanov, Irina A Boyarskaya, Kristina E Borovkova, Lia R Nikiforova, Julia V Salmova, Nikolay V Ul'yanovskii, Dmitry S Kosyakov and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mikhail V KalyaevDepartment of Chemistry, Saint Petersburg State Forest Technical University, Institutsky Per., 5, 194021 Saint Petersburg, Russia.ORCID 0000-0002-4329-5131
Dmitry S RyabukhinDepartment of Chemistry, Saint Petersburg State Forest Technical University, Institutsky Per., 5, 194021 Saint Petersburg, Russia.ORCID 0000-0001-5345-0038
Marina A BorisovaDepartment of Chemistry, Saint Petersburg State Forest Technical University, Institutsky Per., 5, 194021 Saint Petersburg, Russia.
Alexander Yu IvanovCenter for Magnetic Resonance, Research Park, Saint Petersburg State University, Universitetskiy Pr., 26, 198504 Saint Petersburg, Russia.ORCID 0000-0002-4228-1248
Irina A BoyarskayaDepartment of Organic Chemistry, Institute of Chemistry, Saint Petersburg State University, Universitetskaya Nab., 7/9, 199034 Saint Petersburg, Russia.
Kristina E BorovkovaResearch and Manufacturing Company «Home of Pharmacy», Zavodskaya St., 3-245, Kuz'molovskiy Settlement, 188663 Saint Petersburg, Russia.ORCID 0000-0003-1571-6549
Lia R NikiforovaResearch and Manufacturing Company «Home of Pharmacy», Zavodskaya St., 3-245, Kuz'molovskiy Settlement, 188663 Saint Petersburg, Russia.ORCID 0000-0001-8710-2023
Julia V SalmovaResearch and Manufacturing Company «Home of Pharmacy», Zavodskaya St., 3-245, Kuz'molovskiy Settlement, 188663 Saint Petersburg, Russia.ORCID 0000-0001-9891-8634
Nikolay V Ul'yanovskiiCore Facility Center "Arktika", Northern (Arctic) Federal University, Nab. Severnoy Dviny, 17, 163002 Arkhangelsk, Russia.
Dmitry S KosyakovCore Facility Center "Arktika", Northern (Arctic) Federal University, Nab. Severnoy Dviny, 17, 163002 Arkhangelsk, Russia.ORCID 0000-0001-5223-6857
Aleksander V VasilyevDepartment of Chemistry, Saint Petersburg State Forest Technical University, Institutsky Per., 5, 194021 Saint Petersburg, Russia.ORCID 0000-0003-3628-1492

Funding

Ministry of Science and Higher Education FSRU-2021-0009Russian Foundation for Basic Research 20-03-00074 А
6 · The paper itself

Abstract

Reactions of 3-(furan-2-yl)propenoic acids and their esters with arenes in Brønsted superacid TfOH affords products of hydroarylation of the carbon-carbon double bond, 3-aryl-3-(furan-2-yl)propenoic acid derivatives. According to NMR and DFT studies, the corresponding O,C-diprotonated forms of the starting furan acids and esters should be reactive electrophilic species in these transformations. Starting compounds and their hydroarylation products, at a concentration of 64 µg/mL, demonstrate good antimicrobial activity against yeast-like fungi

Indexed as

Anti-Infective AgentsPropionatesCarbonEscherichia coliEstersFuransMicrobial Sensitivity TestsAnti-Infective AgentsCarbonEstersFuransPropionatesantibacterial activitycarbocationsFriedel–Crafts reactionfuranssuperelectrophilic activation

Identifiers

PMID35889484
PMCPMC9325161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.