Evidence map›Paper›PMID 35889364›Full record

ArticleMolecules (Basel, Switzerland)2022

Kinetic Characteristics of Curcumin and Germacrone in Rat and Human Liver Microsomes: Involvement of CYP Enzymes.

Shaofeng Su, Hongxian Wu, Jingfan Zhou, Guangwei Yuan, Haibo Wang, Jie Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shaofeng SuSchool of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530021, China.
Hongxian WuSchool of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530021, China.
Jingfan ZhouSchool of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530021, China.
Guangwei YuanGuangxi-ASEAN Food Inspection and Testing Center, Nanning 530029, China.
Haibo WangGuangxi-ASEAN Food Inspection and Testing Center, Nanning 530029, China.
Jie FengSchool of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530021, China.
Guangxi Medical University · CNGuangxi Special Equipment Inspection Institute · CN

Funding

National Natural Science Developmentation of China 31160077Natural Science Foundation of Guangxi Province of China 2010GXNSFD013044
6 · The paper itself

Abstract

Curcumin and germacrone, natural products present in the Zingiberaceae family of plants, have several biological properties. Among these properties, the anti-NSCLC cancer action is noteworthy. In this paper, kinetics of the two compounds in rat liver microsomes (RLMs), human liver microsomes (HLMs), and cytochrome P450 (CYP) enzymes (CYP3A4, 1A2, 2E1, and 2C19) in an NADPH-generating system in vitro were evaluated by UP-HPLC-MS/MS (ultrahigh-pressure liquid chromatography-tandem mass spectrometry). The contents of four cytochrome P450 (CYP) enzymes, adjusting by the compounds were detected using Western blotting in vitro and in vivo. The t

Indexed as

CurcuminMicrosomes, LiverAnimalsCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemHumansRatsSesquiterpenes, GermacraneTandem Mass SpectrometryCurcuminCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemgermacroneSesquiterpenes, Germacranecurcumincytochrome P450 enzymesdrug–drug interactiongermacroneUPLC–MS/MS

Identifiers

PMID35889364
PMCPMC9317718
OpenAlexW4285387456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.