Evidence map›Paper›PMID 35889075›Full record

ArticleMicroorganisms2022

Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization.

Lukas Zemaitis, Gediminas Alzbutas, Dovydas Gecys, Arnoldas Pautienius, Rasa Ugenskiene, Marius Sukys, Vaiva Lesauskaite

Abstract read
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. SARS-CoV-2 Variants Monitoring Using Real-Time PCR.Diagnostics (Basel, Switzerland) · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lukas ZemaitisLaboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania.ORCID 0000-0001-8060-7395
Gediminas AlzbutasLaboratory of Translational Bioinformatics, Institute for Digestive Research, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania.
Dovydas GecysLaboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania.ORCID 0000-0002-2056-7528
Arnoldas PautieniusInstitute of Microbiology and Virology, Lithuanian University of Health Sciences, LT-47181 Kaunas, Lithuania.ORCID 0000-0002-4494-2724
Rasa UgenskieneDepartment of Genetics and Molecular Medicine, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Marius SukysDepartment of Genetics and Molecular Medicine, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Vaiva LesauskaiteLaboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, LT-50162 Kaunas, Lithuania.ORCID 0000-0003-2736-3111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we report the emergence of the variant lineage B.1.1.523 that contains a set of mutations including 156_158del, E484K and S494P in the spike protein. E484K and S494P are known to significantly reduce SARS-CoV-2 neutralization by convalescent and vaccinated sera and are considered as mutations of concern. Lineage B.1.1.523 presumably originated in the Russian Federation and spread across European countries with the peak of transmission in April-May 2021. The B.1.1.523 lineage has now been reported from 31 countries. In this article, we analyze the possible origin of this mutation subset and its immune response using in silico methods.

Indexed as

B.1.1.523GISAIDphylogenySARS-CoV-2variant of concern (VOC)

Identifiers

PMID35889075
PMCPMC9320768

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.