Evidence map›Paper›PMID 35889055›Full record

ArticleMicroorganisms2022

Nisin and Nisin Probiotic Disrupt Oral Pathogenic Biofilms and Restore Their Microbiome Composition towards Healthy Control Levels in a Peri-Implantitis Setting.

Allan Radaic, Hanna Brody, Fernando Contreras, Maryam Hajfathalian, Luke Lucido, Pachiyappan Kamarajan, Yvonne L Kapila

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Probiotics alleviate oral microbiota disruptions induced byFrontiers in cellular and infection microbiology · 2026
    Trial
  2. Article
  3. Review
  4. Article
  5. Preparation and In Vitro Characterization ofJournal of functional biomaterials · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. The impact ofFrontiers in microbiology · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Allan RadaicDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-0899-9061
Hanna BrodyDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA 94143, USA.
Fernando ContrerasDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA 94143, USA.
Maryam HajfathalianDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA 94143, USA.
Luke LucidoDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA 94143, USA.
Pachiyappan KamarajanDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA 94143, USA.
Yvonne L KapilaDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA 94143, USA.
University of California, San Francisco · USUniversity of California, Los Angeles · US

Funding

Treponema - Host Cell and Tissue InteractionsR01DE025225 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI J CHRISTOPHER FENNO, Yvonne L Kapila · 2015 to 2026
$6.3M
Anti-biofilm laser-mediated photothermal ablation via complex noble metal nanostructuresK99EB028838 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI HAJFATHALIAN, MARYAM · 2020 to 2022
$248k
2020 IADR / Academy of Osseointegration Innovation in Implant Sciences Award N/ANIBIB NIH HHS K99 EB028838NIDCR NIH HHS R01 DE025225NIH HHS 1K99EB028838-01A1NIH HHS R01 DE025225
6 · The paper itself

Abstract

Peri-implantitis is characterized by chronic inflammation of the peri-implant supporting tissues that progressively and irreversibly leads to bone loss and, consequently, implant loss. Similar to periodontal disease, oral dysbiosis is thought to be a driver of peri-implantitis. However, managing peri-implantitis with traditional treatment methods, such as nonsurgical debridement or surgery, is not always successful. Thus, novel strategies have been proposed to address these shortcomings. One strategy is the use of probiotics as antimicrobial agents since they are considered safe for humans and the environment. Specifically, the probiotic

Indexed as

dental implantsLactococcus lactisnisinoral biofilmperi-implantitistitanium discs

Identifiers

PMID35889055
PMCPMC9324437
OpenAlexW4283803019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.