Evidence map›Paper›PMID 35889023›Full record

ArticleMicroorganisms2022

Transcriptome Analysis of Intracellular Amastigotes of Clinical

Raquel García-Hernández, Ana Perea-Martínez, José Ignacio Manzano, Laura C Terrón-Camero, Eduardo Andrés-León, Francisco Gamarro

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Molecular Mechanisms of Drug Resistance inPathogens (Basel, Switzerland) · 2024
    Review
  2. Deciphering Host-Parasite Interplay inACS infectious diseases · 2024
    Article
  3. Deciphering Host-Parasite Interplay inACS infectious diseases · 2024
    Article
  4. Advances inMicroorganisms · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Raquel García-HernándezInstituto de Parasitología y Biomedicina "López-Neyra", IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento 17, Armilla, 18016 Granada, Spain.
Ana Perea-MartínezInstituto de Parasitología y Biomedicina "López-Neyra", IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento 17, Armilla, 18016 Granada, Spain.
José Ignacio ManzanoInstituto de Parasitología y Biomedicina "López-Neyra", IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento 17, Armilla, 18016 Granada, Spain.
Laura C Terrón-CameroInstituto de Parasitología y Biomedicina "López-Neyra", IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento 17, Armilla, 18016 Granada, Spain.
Eduardo Andrés-LeónInstituto de Parasitología y Biomedicina "López-Neyra", IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento 17, Armilla, 18016 Granada, Spain.ORCID 0000-0002-0621-9914
Francisco GamarroInstituto de Parasitología y Biomedicina "López-Neyra", IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento 17, Armilla, 18016 Granada, Spain.
Instituto de Parasitología y Biomedicina "López - Neyra" · ES

Funding

Ministerio de Ciencia, Innovación y Universidades Grant RTI2018-097210-B-100 (Francisco Gamarro), funded by MCIN/AEI/10.13039/501100011033 and by "ERDF A way of making Europe".
6 · The paper itself

Abstract

Leishmaniasis is considered to be one of the most neglected tropical diseases affecting humans and animals around the world. Due to the absence of an effective vaccine, current treatment is based on chemotherapy. However, the continuous appearance of drug resistance and therapeutic failure (TF) lead to an early obsolescence of treatments. Identification of the factors that contribute to TF and drug resistance in leishmaniasis will constitute a useful tool for establishing future strategies to control this disease. In this manuscript, we evaluated the transcriptomic changes in the intracellular amastigotes of the

Indexed as

differential gene expressiondrug-resistant parasiteshost infectionintracellular amastigotesLeishmania infantumRNA-seqtherapeutic failure clinical parasitestranscriptomic analysis

Identifiers

PMID35889023
PMCPMC9324091
OpenAlexW4283652742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.