Evidence map›Paper›PMID 35888978›Full record

ArticleMicroorganisms2022

The Current Knowledge on the Pathogenesis of Tissue and Medical Device-Related Biofilm Infections.

Enea Gino Di Domenico, Alessandra Oliva, María Guembe

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 91 citations in OpenAlex.

  1. Review
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  5. EthanolicMicroorganisms · 2026
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  20. Meropenem/vaborbactam activity against carbapenem-resistantFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Enea Gino Di DomenicoDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6295-6006
Alessandra OlivaDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0832-7975
María GuembeDepartment of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0002-7607-5848
Sapienza University of Rome · ITHospital General Universitario Gregorio Marañón · ES

Funding

Instituto de Salud Carlos III MSII18/00008
6 · The paper itself

Abstract

Biofilm is the trigger for the majority of infections caused by the ability of microorganisms to adhere to tissues and medical devices. Microbial cells embedded in the biofilm matrix are highly tolerant to antimicrobials and escape the host immune system. Thus, the refractory nature of biofilm-related infections (BRIs) still represents a great challenge for physicians and is a serious health threat worldwide. Despite its importance, the microbiological diagnosis of a BRI is still difficult and not routinely assessed in clinical microbiology. Moreover, biofilm bacteria are up to 100-1000 times less susceptible to antibiotics than their planktonic counterpart. Consequently, conventional antibiograms might not be representative of the bacterial drug susceptibility in vivo. The timely recognition of a BRI is a crucial step to directing the most appropriate biofilm-targeted antimicrobial strategy.

Indexed as

biofilmclinical impactdevicespathogenesistissues

Identifiers

PMID35888978
PMCPMC9322301
OpenAlexW4283374028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.