Evidence map›Paper›PMID 35888961›Full record

ArticleMicromachines2022

Enzymatic and Cellular Degradation of Carbon-Based Biconcave Nanodisks.

Zhiyong Wei, Qingxin Mu, Hui Wang, Guanyou Lin, Miqin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Sub-Toxic Exposure to DEPs and PMJournal of xenobiotics · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Zhiyong WeiDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5477-9502
Qingxin MuDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-4952-6591
Hui WangDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Guanyou LinDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-1706-5463
Miqin ZhangDepartment of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-8974-1494
University of Washington · US

Funding

Iron oxide nanotheranostics for breast cancerR01EB026890 · NIBIB · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2018 to 2021
$1.9M
NIBIB NIH HHS R01 EB026890NIH HHS R01EB026890
6 · The paper itself

Abstract

The assessment of the biodegradability of nanomaterials is of pragmatic importance for understanding the interactions between nanomaterials and biological systems and for the determination of ultimate fate of these materials as well as their potential use. We recently developed carbon-based biconcave nanodisks (CBBNs) serving as a versatile nanocarrier for enhanced accumulation in tumors and combined photothermal-chemotherapy. Here, we investigate both the enzymatic and cellular degradation of CBBNs by monitoring their cellular response with electron microscopy, near-infrared absorbance spectroscopy, and cell viability and oxidative stress assessments. Our results show that CBBNs underwent significant degradation in solutions catalyzed by horseradish peroxidase (HRP) and hydrogen peroxide (H

Indexed as

biconcave nanodiskscarbon-based nanoparticlescellular degradationenzymatic degradation

Identifiers

PMID35888961
PMCPMC9322382
OpenAlexW4286214484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.