Evidence map›Paper›PMID 35888740›Full record

ArticleMetabolites2022

The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium.

Mijin Jung, Xiaobei Pan, Emma L Cunningham, Anthony P Passmore, Bernadette McGuinness, Daniel F McAuley, David Beverland, Seamus O'Brien, Tim Mawhinney, Jonathan M Schott and 2 more

Abstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mijin JungInstitute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 8 Malone Road, Belfast BT9 5BN, Northern Ireland, UK.
Xiaobei PanInstitute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 8 Malone Road, Belfast BT9 5BN, Northern Ireland, UK.
Emma L CunninghamCentre for Public Health, Institute of Clinical Sciences, Queen's University Belfast, Block B, Royal Victoria Hospital Site, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK.
Anthony P PassmoreCentre for Public Health, Institute of Clinical Sciences, Queen's University Belfast, Block B, Royal Victoria Hospital Site, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK.
Bernadette McGuinnessCentre for Public Health, Institute of Clinical Sciences, Queen's University Belfast, Block B, Royal Victoria Hospital Site, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK.ORCID 0000-0002-7028-5633
Daniel F McAuleyCentre for Experimental Medicine, Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.ORCID 0000-0002-3283-1947
David BeverlandOutcomes Assessment Unit, Musgrave Park Hospital, Belfast Trust, Stockman's Lane, Belfast BT9 7JB, Northern Ireland, UK.
Seamus O'BrienCardiac Surgical Intensive Care Unit, Belfast Trust, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK.
Tim MawhinneyCardiac Surgical Intensive Care Unit, Belfast Trust, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK.
Jonathan M SchottDepartment of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1E 6BT, UK.
Henrik ZetterbergDepartment of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1E 6BT, UK.
Brian D GreenInstitute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 8 Malone Road, Belfast BT9 5BN, Northern Ireland, UK.ORCID 0000-0003-3331-0032

Funding

Are the impairments of arginine metabolism as found in Alzheimer's disease also present in patients developing post-operative delirium and cognitive decline?R21AG067083 · NIA · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · PI CUNNINGHAM, EMMA LOUISE, GRAHAM, STEWART F · 2020 to 2020
$330k
AD Strategic Fund and the Alzheimer's Association #ADSF-21-831376-CAlzheimer Drug Discovery Foundation #201809-2016862Alzheimer's Research UK ARUK-CRF2018C-001Alzheimer's Research UK ARUK-NC2019-NIEuropean Research Council #681712European Union Joint Program for Neurodegenerative Disorders JPND2021-00694European Union's Horizon 2020 research and innovation programme No 860197InvestNI RD101427 11-01-17-008Medical Research Council CIC-CD1718-CIC25NIA NIH HHS R21 AG067083NIH HHS R21AG067083-01Olav Thon Foundation #FO2019-0228Swedish Research Council #2018-02532Swedish State Support for Clinical Research #ALFGBG-720931US-Ireland Health and Social Care NI HSC R&DST/5460/2018
6 · The paper itself

Abstract

The mechanisms underlying the occurrence of postoperative delirium development are unclear and measurement of plasma metabolites may improve understanding of its causes. Participants (

Indexed as

ornithineorthopedic surgerypolyaminepostoperative deliriumspermine

Identifiers

PMID35888740
PMCPMC9319890

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.