Evidence map›Paper›PMID 35888705›Full record

ArticleMetabolites2022

Comparative Metabolomics Study of the Impact of Articaine and Lidocaine on the Metabolism of SH-SY5Y Neuronal Cells.

Gustavo H Rodrigues da Silva, Luís F Mendes, Fabíola V de Carvalho, Eneida de Paula, Iola F Duarte

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Engineered bone-targetingMaterials today. Bio · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Gustavo H Rodrigues da SilvaCICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0001-7377-8532
Luís F MendesCICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Fabíola V de CarvalhoDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas 13083-862, SP, Brazil.ORCID 0000-0002-4450-0563
Eneida de PaulaDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas 13083-862, SP, Brazil.ORCID 0000-0003-4504-5723
Iola F DuarteCICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0003-4289-9256
Universidade Estadual de Campinas (UNICAMP) · BRUniversity of Aveiro · PT

Funding

Fundação para a Ciência e Tecnologia UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020São Paulo Research Foundation 18/24814-0, 14/25372-0
6 · The paper itself

Abstract

Articaine (ATC) and lidocaine (LDC) are the local anesthetics (LAs) currently most employed in dentistry. Cases of paresthesia, reported more frequently for ATC, have raised concerns about their potential neurotoxicity, calling for further investigation of their biological effects in neuronal cells. In this work, the impact of ATC and LDC on the metabolism of SH-SY5Y cells was investigated through

Indexed as

articaine and lidocainelocal anestheticsneuronal cellsneurotoxicitytoxicometabolomics

Identifiers

PMID35888705
PMCPMC9323911
OpenAlexW4283311973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.