Evidence map›Paper›PMID 35888162›Full record

ReviewLife (Basel, Switzerland)2022

Pathogenesis of Distal Symmetrical Polyneuropathy in Diabetes.

Sasha Smith, Pasha Normahani, Tristan Lane, David Hohenschurz-Schmidt, Nick Oliver, Alun Huw Davies

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Observational
  13. Review
  14. An Overview on Diabetic Neuropathy.Current diabetes reviews · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. Obstetric Neuropathy in Diabetic Patients: The "Double Hit Hypothesis".International journal of molecular sciences · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sasha SmithSection of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London W6 8RF, UK.ORCID 0000-0001-9843-5368
Pasha NormahaniSection of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London W6 8RF, UK.
Tristan LaneSection of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London W6 8RF, UK.ORCID 0000-0002-8681-7075
David Hohenschurz-SchmidtPain Research Group, Department of Surgery and Cancer, Imperial College London, London SW10 9NH, UK.
Nick OliverSection of Metabolic Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W2 1PG, UK.ORCID 0000-0003-3525-3633
Alun Huw DaviesSection of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London W6 8RF, UK.
Imperial College Healthcare NHS Trust · GBCambridge University Hospitals NHS Foundation Trust · GBImperial College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Distal symmetrical polyneuropathy (DSPN) is a serious complication of diabetes associated with significant disability and mortality. Although more than 50% of people with diabetes develop DSPN, its pathogenesis is still relatively unknown. This lack of understanding has limited the development of novel disease-modifying therapies and left the reasons for failed therapies uncertain, which is critical given that current management strategies often fail to achieve long-term efficacy. In this article, the pathogenesis of DSPN is reviewed, covering pathogenic changes in the peripheral nervous system, microvasculature and central nervous system (CNS). Furthermore, the successes and limitations of current therapies are discussed, and potential therapeutic targets are proposed. Recent findings on its pathogenesis have called the definition of DSPN into question and transformed the disease model, paving the way for new research prospects.

Indexed as

central nervous systemdiabetesdiabetic neuropathydistal symmetrical polyneuropathyglycemic controlhyperglycemianeuropathic painpain managementpathogenesisspinal cord stimulation

Identifiers

PMID35888162
PMCPMC9319251
OpenAlexW4285799433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.