Evidence map›Paper›PMID 35888115›Full record

ArticleLife (Basel, Switzerland)2022

Prothrombinase-Induced Clotting Time to Measure Drug Concentrations of Rivaroxaban, Apixaban, and Edoxaban in Clinical Practice: A Cross-Sectional Study.

Vepusha Sathanantham, Lorenzo Alberio, Cédric Bovet, Pierre Fontana, Bernhard Gerber, Lukas Graf, Adriana Mendez, Thomas C Sauter, Adrian Schmidt, Jan-Dirk Studt and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Vepusha SathananthamDepartment of Clinical Chemistry, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.
Lorenzo AlberioService and Central Laboratory of Hematology, CHUV, Lausanne University Hospital, 1011 Lausanne, Switzerland.ORCID 0000-0001-9686-9920
Cédric BovetDepartment of Clinical Chemistry, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.
Pierre FontanaDivision of Angiology and Hemostasis, Geneva University Hospital, 1205 Geneva, Switzerland.ORCID 0000-0003-1546-0774
Bernhard GerberClinic of Hematology, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland.
Lukas GrafCentre for Laboratory Medicine St. Gallen, 9001 St. Gallen, Switzerland.
Adriana MendezDepartment of Laboratory Medicine, Cantonal Hospital Aarau, 5001 Aarau, Switzerland.
Thomas C SauterDepartment of Emergency Medicine, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.
Adrian SchmidtClinic of Medical Oncology and Hematology, Institute of Laboratory Medicine, City Hospital Waid and Triemli, 8063 Zurich, Switzerland.
Jan-Dirk StudtDivision of Medical Oncology and Hematology, University and University Hospital Zurich, 8091 Zurich, Switzerland.
Walter A WuilleminDivision of Hematology and Central Hematology Laboratory, Cantonal Hospital of Lucerne, 6000 Lucerne, Switzerland.
Michael NaglerDepartment of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-4319-2367
University Hospital of Bern · CHKantonsspital Aarau · CHTriemli Hospital · CHUniversity Hospital of Geneva · CHUniversity Hospital of Zurich · CHUniversity of Bern · CHUniversity of St.Gallen · CHUniversity of Zurich · CH

Funding

Gottfried und Julia Bangerter-Rhyner-Stiftung N/AResearch Fund Haematology Cantonal Hospital Lucerne N/ASwiss National Science Foundation 179334
6 · The paper itself

Abstract

Prothrombinase-induced clotting time (PiCT) is proposed as a rapid and inexpensive laboratory test to measure direct oral anticoagulant (DOAC) drug levels. In a prospective, multicenter cross-sectional study, including 851 patients, we aimed to study the accuracy of PiCT in determining rivaroxaban, apixaban, and edoxaban drug concentrations and assessed whether clinically relevant drug levels could be predicted correctly. Citrated plasma samples were collected, and the Pefakit

Indexed as

apixabancross-sectional studiesdiagnostic accuracydirect oral anticoagulantsedoxabanlaboratory monitoringprothrombinase-induced clotting timerivaroxabansensitivity and specificity

Identifiers

PMID35888115
PMCPMC9324795
OpenAlexW4285035874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.