ReviewJournal of clinical medicine2022
Pleomorphic Adenoma of the Salivary Glands and Epithelial-Mesenchymal Transition.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- A case report of pleomorphic adenoma in a 27-year-old female.Radiology case reports · 2026Article
- Patient-derived 3D organotypic co-cultures as a long-term ex vivo model for pleomorphic adenoma of the parotid gland.Scientific reports · 2026Article
- Pleomorphic Adenomas and Their Atypical Morphology: Pitfalls in the Diagnosis of Salivary Gland Tumors.Diagnostics (Basel, Switzerland) · 2026Review
- The paradox of benign histology and malignant behavior: lymphatic metastasis in pleomorphic adenoma-a case report.Journal of medical case reports · 2026Article
- Role of Ki-67 and Annexin V in the Biological Behavior of Salivary Gland Tumors: Insights into Proliferation and Apoptosis.Current issues in molecular biology · 2026Article
- Added value of slow diffusion coefficient (SDC) for the separation of benign and malignant parotid gland tumors by diffusion weighted imaging: preliminary results.BMC medical imaging · 2025Article
- Recurrence of Pleomorphic Adenoma in the Submandibular Gland: A Case Report and Literature ReviewCurrent medical imaging · 2025Review
- Intraoral Pleomorphic Adenoma of the Minor Salivary Glands: A Case Series of 10 Cases With Emphasis on Histopathological Features.Case reports in dentistry · 2025Article
- Pleomorphic adenoma parotid surgery, how much margin we can reach to be safe?Dental research journal · 2025Article
- Natural course of apparent diffusion coefficient (ADC) change after brain ischemic stroke: an alternative explanation by the triphasic relationship between T2 and ADC.Quantitative imaging in medicine and surgery · 2024Article
- Clinical and Morphological Aspects of Aggressive Salivary Gland Mixed Tumors: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Transcription factor FoxO1 regulates myoepithelial cell diversity and growth.Scientific reports · 2024Article
- Case Series: Pleomorphic adenoma in minor salivary gland.F1000Research · 2024Article
- Hypoxia-Induced Biosynthesis of the Extracellular Matrix Molecules, Perlecan and Fibronectin, Promotes the Growth of Pleomorphic Adenoma Cells In Vitro Models.Biomedicines · 2023Article
- Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma.International journal of oral science · 2023Article
- Review
- Special Issue "Diseases of the Salivary Glands-Part II".Journal of clinical medicine · 2022Article
- Primary cell culture and characterization of a pleomorphic adenoma. A case report.Revista cientifica odontologica (Universidad Cientifica del Sur)Article
- Animal metaphors in oral pathology-A review.Journal of oral and maxillofacial pathology : JOMFPReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pleomorphic adenoma (PA) is a localized tumor that presents pleomorphic or mixed characteristics of epithelial origin and is interwoven with mucoid tissue, myxoid tissue, and chondroid masses. The literature reported that PA most often occurs in adults aged 30-60 years and is a female predilection; the exact etiology remains unclear. Epithelial-mesenchymal transition (EMT) is the transdifferentiation of stationary epithelial cells primarily activated by a core set of transcription factors (EMT-TFs) involved in DNA repair and offers advantages under various stress conditions. Data have suggested that EMTs represent the basic principle of tissue heterogeneity in PAs, demonstrating the potential of adult epithelial cells to transdifferentiate into mesenchymal cells. It has also been reported that multiple TFs, such as TWIST and SLUG, are involved in EMT in PA and that SLUG could play an essential role in the transition from myoepithelial to mesenchymal cells. Given this background, this review aims to summarize and clarify the involvement of EMT in the development of PA, chondrocyte differentiation, and malignant transformation to contribute to the fundamental elucidation of the mechanisms underlying EMT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.