ReviewJournal of clinical medicine2022
Digital Cognitive Biomarker for Mild Cognitive Impairments and Dementia: A Systematic Review.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
- Diagnostic accuracy of a self-administered digital cognitive test battery for differentiating early Alzheimer's disease from controls.European archives of psychiatry and clinical neuroscience · 2026Trial
- Primary care determinants for timely diagnosis of dementia.Family medicine and community health · 2026Article
- Scenario-Based Serious Game for Screening Mild Cognitive Impairment in Older Adults: Cross-Sectional Preliminary Validation Study.JMIR serious games · 2026Article
- Real-Time Smartphone Monitoring Assessments as a Cognitive Biomarker of Alzheimer Disease: Protocol for a Development Study.JMIR research protocols · 2026Article
- Age-Adjusted CKPT App Profiling and Mobility Profiles in Community-Dwelling Older Adults with Near-Ceiling MMSE Scores: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Artificial intelligence in nursing practice for older adults with dementia: A narrative review informed by bibliometric mapping and implications for nurse-led research.Journal of Korean gerontological nursing · 2026Article
- Research on Threshold Optimization and Variability-Based Digital Biomarker Approaches Through MMSE-Lifelog Multimodal Integrated Analysis from a Clinical Screening Perspective.Healthcare (Basel, Switzerland) · 2026Article
- Beyond single-modality screening: toward an EEG-IoT dual-stream framework for early detection of mild cognitive impairment in community-dwelling older adults.Frontiers in aging neuroscience · 2026Article
- Listening for Alzheimer's clues: machine learning analysis of multidomain speech features for cognitive impairment screening.Frontiers in aging neuroscience · 2026Article
- Development and Validation of the Short-Form BrainOK: An Efficient Digital Screening Tool for Mild Cognitive Impairment.Diagnostics (Basel, Switzerland) · 2025Article
- Machine learning-based estimation of the mild cognitive impairment stage using multimodal physical and behavioral measures.Scientific reports · 2025Article
- Digital Twin Cognition: AI-Biomarker Integration in Biomimetic Neuropsychology.Biomimetics (Basel, Switzerland) · 2025Review
- Optimizing mobile cognitive assessment reduces administration time while maintaining screening accuracy in older adults.Scientific reports · 2025Article
- Longitudinal Remote Sleep and Cognitive Research in Older Adults With Mild Cognitive Impairment and Dementia: Prospective Feasibility Cohort Study.JMIR aging · 2025Article
- A New Computer-Based Cognitive Measure for Early Detection of Dementia Risk (Japan Cognitive Function Test): Validation Study.Journal of medical Internet research · 2025Article
- Glymphatic function decline as a mediator of core memory-related brain structures atrophy in aging.Journal of translational internal medicine · 2025Article
- Differential cognitive functioning in the digital clock drawing test in AD-MCI and PD-MCI populations.Frontiers in neuroscience · 2025Article
- The Association Between Cognitive Functioning and Depression Severity: A Multiwave Longitudinal Remote Assessment Study.Depression and anxiety · 2025Article
- FACEmemoryJournal of clinical medicine · 2024Article
- Cognitive modeling of the Mnemonic Similarity Task as a digital biomarker for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The dementia population is increasing as the world's population is growing older. The current systematic review aims to identify digital cognitive biomarkers from computerized tests for detecting dementia and its risk state of mild cognitive impairment (MCI), and to evaluate the diagnostic performance of digital cognitive biomarkers. A literature search was performed in three databases, and supplemented by a Google search for names of previously identified computerized tests. Computerized tests were categorized into five types, including memory tests, test batteries, other single/multiple cognitive tests, handwriting/drawing tests, and daily living tasks and serious games. Results showed that 78 studies were eligible. Around 90% of the included studies were rated as high quality based on the Newcastle-Ottawa Scale (NOS). Most of the digital cognitive biomarkers achieved comparable or even better diagnostic performance than traditional paper-and-pencil tests. Moderate to large group differences were consistently observed in cognitive outcomes related to memory and executive functions, as well as some novel outcomes measured by handwriting/drawing tests, daily living tasks, and serious games. These outcomes have the potential to be sensitive digital cognitive biomarkers for MCI and dementia. Therefore, digital cognitive biomarkers can be a sensitive and promising clinical tool for detecting MCI and dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.