Evidence map›Paper›PMID 35887884›Full record

ArticleJournal of clinical medicine2022

Decreased Left Atrial Reservoir Strain Is Associated with Adverse Outcomes in Restrictive Cardiomyopathy.

Jadranka Stojanovska, Nevriye Topaloglu, Kana Fujikura, Behnaz Khazai, El-Sayed Ibrahim, Alex Tsodikov, Nicole M Bhave, Theodore J Kolias

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jadranka StojanovskaDepartment of Biomedical Imaging, New York University Langone Medical Center, New York, NY 10016, USA.
Nevriye TopalogluMichigan Medicine and School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7763-9097
Kana FujikuraNational Heart, Lung and Blood Institute, National Institute of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-7610-850X
Behnaz KhazaiMichigan Medicine and School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
El-Sayed IbrahimDepartment of Radiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0003-4292-4669
Alex TsodikovMichigan Medicine and School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Nicole M BhaveMichigan Medicine and School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Theodore J KoliasMichigan Medicine and School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Michigan Medicine · USMedical College of Wisconsin · USNational Heart Lung and Blood Institute · USNYU Langone Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Restrictive cardiomyopathy (RCM) places patients at high risk for adverse events. In this study, we aim to evaluate the association between left atrial function and time to adverse events such as all-cause mortality and cardiovascular hospitalizations related to RCM. Material and Methods: In this single-center study, ninety-eight patients with a clinical diagnosis of RCM were recruited from our registry: 30 women (31%); age (mean ± standard deviation) 61 ± 13 years. These patients underwent cardiac magnetic resonance (CMR) imaging from May 2007 to September 2015. Left atrial (LA) function (reservoir, contractile, and conduit strain), LA diameter and area, and left ventricular function (global longitudinal strain, ejection fraction), and volume were quantified, and the presence of late gadolinium enhancement was visually assessed. The cutoff value of the LA reservoir strain was selected based on tertile. An adjusted Cox proportional regression analysis was used to assess time to adverse outcomes with a median follow up of 49 months. Results: In our cohort, all-cause mortality was 36% (35/98). Composite events (all-cause mortality and cardiovascular hospitalizations) occurred in 56% of patients (55/98). All-cause mortality and composite events were significantly associated with a decreased LA reservoir strain (adjusted hazard ratio (aHR) = 0.957, p = 0.002 and aHR = 0.969, p = 0.008) using a stepwise elimination of imaging variables, demographics, and comorbidities. All-cause mortality and composite events were six and almost four times higher, respectively, in patients with the LA reservoir strain <15% (aHR = 5.971, p = 0.005, and HR = 4.252, p = 0.001) compared to patients with the LA reservoir strain >34%. Survival was significantly reduced in patients with an LA reservoir strain <15% (p = 0.008). Conclusions: The decreased LA reservoir strain is independently associated with time to adverse events in patients with RCM.

Indexed as

cardiac magnetic resonanceleft atrial arealeft atrial reservoir strainrestrictive cardiomyopathysurvival analyses

Identifiers

PMID35887884
PMCPMC9316068
OpenAlexW4285733786

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.