Evidence map›Paper›PMID 35887547›Full record

ReviewJournal of personalized medicine2022

The Current State of Radiotherapy for Pediatric Brain Tumors: An Overview of Post-Radiotherapy Neurocognitive Decline and Outcomes.

Nicholas Major, Neal A Patel, Josiah Bennett, Ena Novakovic, Dana Poloni, Mickey Abraham, Nolan J Brown, Julian L Gendreau, Ronald Sahyouni, Joshua Loya

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Efficacy and safety of dabrafenib plus trametinib in pediatric versus adult gliomas: a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicholas MajorSchool of Medicine, Mercer University School of Medicine, Savannah, GA 31404, USA.
Neal A PatelSchool of Medicine, Mercer University School of Medicine, Savannah, GA 31404, USA.
Josiah BennettSchool of Medicine, Mercer University School of Medicine, Savannah, GA 31404, USA.
Ena NovakovicSchool of Medicine, Mercer University School of Medicine, Savannah, GA 31404, USA.
Dana PoloniDepartment of Surgery, Eisenhower Army Medical Center, Augusta, GA 30905, USA.
Mickey AbrahamDepartment of Neurosurgery, University of California San Diego, San Diego, CA 92103, USA.
Nolan J BrownDepartment of Neurosurgery, University of California Irvine, Orange, CA 92868, USA.ORCID 0000-0002-6025-346X
Julian L GendreauJohns Hopkins Whiting School of Engineering, Baltimore, MD 21218, USA.
Ronald SahyouniDepartment of Neurosurgery, University of California San Diego, San Diego, CA 92103, USA.ORCID 0000-0002-2124-0535
Joshua LoyaDepartment of Neurosurgery, University of California San Diego, San Diego, CA 92103, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumors of the central nervous system are the most common solid malignancies diagnosed in children. While common, they are also found to have some of the lowest survival rates of all malignancies. Treatment of childhood brain tumors often consists of operative gross total resection with adjuvant chemotherapy or radiotherapy. The current body of literature is largely inconclusive regarding the overall benefit of adjuvant chemo- or radiotherapy. However, it is known that both are associated with conditions that lower the quality of life in children who undergo those treatments. Chemotherapy is often associated with nausea, emesis, significant fatigue, immunosuppression, and alopecia. While radiotherapy can be effective for achieving local control, it is associated with late effects such as endocrine dysfunction, secondary malignancy, and neurocognitive decline. Advancements in radiotherapy grant both an increase in lifetime survival and an increased lifetime for survivors to contend with these late effects. In this review, the authors examined all the published literature, analyzing the results of clinical trials, case series, and technical notes on patients undergoing radiotherapy for the treatment of tumors of the central nervous system with a focus on neurocognitive decline and survival outcomes.

Indexed as

clinical outcomesglioblastomagliomamedulloblastomaneurocognitive declinepediatricpilocytic astrocytomaquality of liferadiotherapysurvivaltumors

Identifiers

PMID35887547
PMCPMC9315742

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.