Evidence map›Paper›PMID 35887380›Full record

ArticleInternational journal of molecular sciences2022

Treatment of Mouse Sperm with a Non-Catalytic Mutant of PLA2G10 Reveals That PLA2G10 Improves In Vitro Fertilization through Both Its Enzymatic Activity and as Ligand of PLA2R1.

Roland Abi Nahed, Magali Dhellemmes, Christine Payré, Emilie Le Blévec, Jean-Philippe Perrier, Sylviane Hennebicq, Jessica Escoffier, Pierre F Ray, Corinne Loeuillet, Gérard Lambeau and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. The Phospholipase AJournal of lipid and atherosclerosis · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Roland Abi NahedUniversité Grenoble Alpes, F-38000 Grenoble, France.ORCID 0000-0002-8767-6462
Magali DhellemmesUniversité Grenoble Alpes, F-38000 Grenoble, France.
Christine PayréInstitut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur, CNRS, Valbonne Sophia Antipolis, F-06560 Valbonne, France.ORCID 0000-0003-3640-5061
Emilie Le BlévecUniversité Grenoble Alpes, F-38000 Grenoble, France.
Jean-Philippe PerrierUniversité Grenoble Alpes, F-38000 Grenoble, France.
Sylviane HennebicqUniversité Grenoble Alpes, F-38000 Grenoble, France.ORCID 0000-0002-1851-6932
Jessica EscoffierUniversité Grenoble Alpes, F-38000 Grenoble, France.
Pierre F RayUniversité Grenoble Alpes, F-38000 Grenoble, France.
Corinne LoeuilletUniversité Grenoble Alpes, F-38000 Grenoble, France.ORCID 0000-0001-6474-4453
Gérard LambeauInstitut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur, CNRS, Valbonne Sophia Antipolis, F-06560 Valbonne, France.ORCID 0000-0002-9239-518X
Christophe ArnoultUniversité Grenoble Alpes, F-38000 Grenoble, France.
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The group X secreted phospholipase A2 (PLA2G10) is present at high levels in mouse sperm acrosome. The enzyme is secreted during capacitation and amplifies the acrosome reaction and its own secretion via an autocrine loop. PLA2G10 also improves the rate of fertilization. In in vitro fertilization (IVF) experiments, sperm from

Indexed as

SemenSpermatozoaAnimalsFertilizationFertilization in VitroGroup X Phospholipases A2LigandsMaleMiceMice, Inbred C57BLGroup X Phospholipases A2Ligandsacrosome reactioncapacitationin vitro fertilizationPLA2G10PLA2R1sperm

Identifiers

PMID35887380
PMCPMC9320362
OpenAlexW4286492140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.