Evidence map›Paper›PMID 35887245›Full record

ArticleInternational journal of molecular sciences2022

The Intracellular Distribution of the Small GTPase Rho5 and Its Dimeric Guanidine Nucleotide Exchange Factor Dck1/Lmo1 Determine Their Function in Oxidative Stress Response.

Linnet Bischof, Franziska Schweitzer, Carolin C Sterk, Jürgen J Heinisch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Linnet BischofDepartment of Genetics, Faculty of Biology/Chemistry, University of Osnabrueck, Barbarastrasse 11, D-49076 Osnabrueck, Germany.
Franziska SchweitzerDepartment of Genetics, Faculty of Biology/Chemistry, University of Osnabrueck, Barbarastrasse 11, D-49076 Osnabrueck, Germany.
Carolin C SterkDepartment of Genetics, Faculty of Biology/Chemistry, University of Osnabrueck, Barbarastrasse 11, D-49076 Osnabrueck, Germany.
Jürgen J HeinischDepartment of Genetics, Faculty of Biology/Chemistry, University of Osnabrueck, Barbarastrasse 11, D-49076 Osnabrueck, Germany.ORCID 0000-0003-4197-4285
Osnabrück University · DE

Funding

Deutsche Forschungsgemeinschaft HE 1880/6-1
6 · The paper itself

Abstract

Rho5, the yeast homolog of human Rac1, is a small GTPase which regulates the cell response to nutrient and oxidative stress by inducing mitophagy and apoptosis. It is activated by a dimeric GEF composed of the subunits Dck1 and Lmo1. Upon stress, all three proteins rapidly translocate from the cell surface (Rho5) and a diffuse cytosolic distribution (Dck1 and Lmo1) to mitochondria, with translocation of the GTPase depending on both GEF subunits. We here show that the latter associate with mitochondria independent from each other and from Rho5. The trapping of Dck1-GFP or GFP-Lmo1 to the mitochondrial surface by a specific nanobody fused to the transmembrane domain (TMD) of Fis1 results in a loss of function, mimicking the phenotypes of the respective gene deletions,

Indexed as

Monomeric GTP-Binding ProteinsSaccharomyces cerevisiae ProteinsDNA-Binding ProteinsGuanidineGuanine Nucleotide Exchange FactorsHumansLIM Domain ProteinsMitochondrial ProteinsNucleotidesOxidative Stressrho GTP-Binding ProteinsSaccharomyces cerevisiaeTranscription FactorsDNA-Binding ProteinsFIS1 protein, S cerevisiaeGuanidineGuanine Nucleotide Exchange FactorsLIM Domain ProteinsLMO1 protein, humanMitochondrial ProteinsMonomeric GTP-Binding ProteinsNucleotidesRHO5 protein, S cerevisiaerho GTP-Binding ProteinsSaccharomyces cerevisiae ProteinsTranscription Factorsmembrane trappingmitochondriaoxidative stressRho-type GTPase

Identifiers

PMID35887245
PMCPMC9317549
OpenAlexW4285728270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.