Evidence map›Paper›PMID 35887221›Full record

ArticleInternational journal of molecular sciences2022

Cranial Base Synchondrosis Lacks PTHrP-Expressing Column-Forming Chondrocytes.

Shawn A Hallett, Annabelle Zhou, Curtis Herzog, Ariel Arbiv, Wanida Ono, Noriaki Ono

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Review
  2. Article
  3. Bone and Cartilage Biology.International journal of molecular sciences · 2023
    Article
  4. Article
  5. Cranial Base Synchondrosis: Chondrocytes at the Hub.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shawn A HallettDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1472-7502
Annabelle ZhouDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
Curtis HerzogDepartment of Oral and Maxillofacial Surgery, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
Ariel ArbivDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
Wanida OnoDepartment of Orthodontics, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX 77054, USA.
Noriaki OnoDepartment of Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX 77054, USA.ORCID 0000-0002-3771-8230
University of Michigan · USThe University of Texas Health Science Center at Houston · US

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Craniofacial skeletal cell lineage plasticity for reconstituting stem cells and their nichesR01DE030630 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI, ONO, WANIDA · 2021 to 2025
$2.2M
Dynamics and Regulations of Bone Stem Cells in VivoR01DE026666 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI · 2018 to 2022
$2.1M
Dental Follicle: A Central Regulator of Tooth Root Formation and RegenerationR01DE029181 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, WANIDA · 2021 to 2025
$1.9M
Unraveling the Cellular Dynamics of the Cranial Base Synchondroses Throughout Postnatal Craniofacial DevelopmentF30DE030675 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HALLETT, SHAWN ALEXANDER · 2021 to 2025
$195k
NIDCR NIH HHS F30 DE030675NIDCR NIH HHS F30DE030675NIDCR NIH HHS R01 DE026666NIDCR NIH HHS R01DE026666NIDCR NIH HHS R01 DE029181NIDCR NIH HHS R01DE029181NIDCR NIH HHS R01 DE030630NIDCR NIH HHS R01DE030630NIDCR NIH HHS T32 DE007057
6 · The paper itself

Abstract

The cranial base contains a special type of growth plate termed the synchondrosis, which functions as the growth center of the skull. The synchondrosis is composed of bidirectional opposite-facing layers of resting, proliferating, and hypertrophic chondrocytes, and lacks the secondary ossification center. In long bones, the resting zone of the epiphyseal growth plate houses a population of parathyroid hormone-related protein (PTHrP)-expressing chondrocytes that contribute to the formation of columnar chondrocytes. Whether PTHrP

Indexed as

ChondrocytesParathyroid Hormone-Related ProteinAnimalsCell DifferentiationEpiphysesGrowth PlateMiceSkull BaseParathyroid Hormone-Related Proteinbone biologycartilagechondrocyte(s)cranial basecraniofacial biology/geneticsdevelopmental biologygrowth/developmentPTHrP

Identifiers

PMID35887221
PMCPMC9315528
OpenAlexW4285731363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.