Evidence map›Paper›PMID 35887190›Full record

ArticleInternational journal of molecular sciences2022

Alcohol Dependence Induces CRF Sensitivity in Female Central Amygdala GABA Synapses.

Larry Rodriguez, Dean Kirson, Sarah A Wolfe, Reesha R Patel, Florence P Varodayan, Angela E Snyder, Pauravi J Gandhi, Sophia Khom, Roman Vlkolinsky, Michal Bajo and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  6. Women and alcohol: A call to action.Alcohol, clinical & experimental research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Larry RodriguezDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-9591-5005
Dean KirsonDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Sarah A WolfeDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Reesha R PatelDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Florence P VarodayanDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Angela E SnyderDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Pauravi J GandhiDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Sophia KhomDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Roman VlkolinskyDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Michal BajoDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Marisa RobertoDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-0729-3961
Scripps Research Institute · US

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI AMANDA J ROBERTS · 2003 to 2026
$46.3M
Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
SYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI KOOB, GEORGE F · 1985 to 2002
$5.1M
Regulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6M
Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependenceR01AA021491 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2013 to 2024
$3.9M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7M
Neuroimmune mechanisms in stress and alcohol comorbidityR01AA027700 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2019 to 2023
$2.4M
Synaptic Mechanisms underlying sex-differences in alcohol use disorderR01AA029841 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2022 to 2026
$2.0M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR01AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2009 to 2013
$1.8M
Hypothalamic oxytocin influence on extended amygdala CRF neurons in alcohol dependenceR00AA026638 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KIRSON, DEAN · 2021 to 2023
$842k
Alcohol-induced neuroadapation of prefrontal cortical projectionsR00AA025408 · NIAAA · STATE UNIVERSITY OF NY,BINGHAMTON · PI VARODAYAN, FLORENCE PRABHA · 2020 to 2022
$747k
NIAAA NIH HHS AA006420NIAAA NIH HHS AA007456NIAAA NIH HHS AA013498NIAAA NIH HHS AA015566NIAAA NIH HHS AA017447NIAAA NIH HHS AA021491NIAAA NIH HHS AA025408NIAAA NIH HHS AA026638NIAAA NIH HHS AA026765NIAAA NIH HHS AA027700NIAAA NIH HHS AA029841NIAAA NIH HHS F32 AA026765NIAAA NIH HHS K99 AA025408NIAAA NIH HHS K99 AA026638NIAAA NIH HHS P50 AA006420NIAAA NIH HHS R00 AA025408NIAAA NIH HHS R00 AA026638NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA021491NIAAA NIH HHS R01 AA027700NIAAA NIH HHS R01 AA029841NIAAA NIH HHS R37 AA017447NIAAA NIH HHS T32 AA007456NIAAA NIH HHS U01 AA013498
6 · The paper itself

Abstract

Alcohol use disorder (AUD) is a chronically relapsing disease characterized by loss of control in seeking and consuming alcohol (ethanol) driven by the recruitment of brain stress systems. However, AUD differs among the sexes: men are more likely to develop AUD, but women progress from casual to binge drinking and heavy alcohol use more quickly. The central amygdala (CeA) is a hub of stress and anxiety, with corticotropin-releasing factor (CRF)-CRF

Indexed as

AlcoholismCentral Amygdaloid NucleusAnimalsCorticotropin-Releasing HormoneEthanolFemalegamma-Aminobutyric AcidHumansMaleRatsReceptors, Corticotropin-Releasing HormoneSynapsesSynaptic TransmissionCorticotropin-Releasing HormoneEthanolgamma-Aminobutyric AcidReceptors, Corticotropin-Releasing Hormonealcohol use disorder (AUD)central amygdala (CeA)corticotropin releasing factor (CRF)Gamma-Aminobutyric Acid (GABA)patch-clamp electrophysiologysex differencespontaneous inhibitory postsynaptic currents (sIPSCs)

Identifiers

PMID35887190
PMCPMC9318832
OpenAlexW4285732791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.