Evidence map›Paper›PMID 35887188›Full record

ArticleInternational journal of molecular sciences2022

Neutrophil Activation by Mineral Microparticles Coated with Methylglyoxal-Glycated Albumin.

Elena V Mikhalchik, Victor A Ivanov, Irina V Borodina, Olga V Pobeguts, Igor P Smirnov, Irina V Gorudko, Daria V Grigorieva, Olga P Boychenko, Alexander P Moskalets, Dmitry V Klinov and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Elena V MikhalchikFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 119435 Moscow, Russia.
Victor A IvanovFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 119435 Moscow, Russia.
Irina V BorodinaFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 119435 Moscow, Russia.
Olga V PobegutsFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 119435 Moscow, Russia.
Igor P SmirnovFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0003-0402-3392
Irina V GorudkoDepartment of Biophysics, Belarusian State University, 220030 Minsk, Belarus.ORCID 0000-0002-4737-470X
Daria V GrigorievaDepartment of Biophysics, Belarusian State University, 220030 Minsk, Belarus.ORCID 0000-0003-0210-5474
Olga P BoychenkoFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0001-6246-7085
Alexander P MoskaletsFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 119435 Moscow, Russia.
Dmitry V KlinovFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 119435 Moscow, Russia.
Oleg M PanasenkoFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, 119435 Moscow, Russia.
Luboff Y FilatovaFaculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
Ekaterina A KirzhanovaFaculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
Nadezhda G BalabushevichFaculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
Federal Medical-Biological Agency · RULomonosov Moscow State University · RUBelarusian State University · BYPeoples' Friendship University of Russia · RUSirius University of Science and Technology · RU

Funding

Development Program of Lomonosov MSU and registration theme 121041500039-8Russian Science Foundation 20-15-00390
6 · The paper itself

Abstract

Hyperglycemia-induced protein glycation and formation of advanced glycation end-products (AGEs) plays an important role in the pathogenesis of diabetic complications and pathological biomineralization. Receptors for AGEs (RAGEs) mediate the generation of reactive oxygen species (ROS) via activation of NADPH-oxidase. It is conceivable that binding of glycated proteins with biomineral particles composed mainly of calcium carbonate and/or phosphate enhances their neutrophil-activating capacity and hence their proinflammatory properties. Our research managed to confirm this hypothesis. Human serum albumin (HSA) was glycated with methylglyoxal (MG), and HSA-MG was adsorbed onto mineral microparticles composed of calcium carbonate nanocrystals (vaterite polymorph, CC) or hydroxyapatite nanowires (CP). As scopoletin fluorescence has shown, H

Indexed as

Neutrophil ActivationPyruvaldehydeCalcium CarbonateGlycated Serum AlbuminGlycation End Products, AdvancedHumansHydrogen PeroxideMineralsNADPNADPH OxidasesSerum AlbuminSerum Albumin, HumanCalcium CarbonateGlycated Serum AlbuminGlycation End Products, AdvancedHydrogen PeroxideMineralsNADPNADPH OxidasesPyruvaldehydeSerum AlbuminSerum Albumin, Humanadvanced glycation end-productsalbuminchemiluminescencediabeteshyperglycemiamethylglyoxalneutrophilsvaterite

Identifiers

PMID35887188
PMCPMC9321525
OpenAlexW4285732789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.