Evidence map›Paper›PMID 35887187›Full record

ArticleInternational journal of molecular sciences2022

A Regulatory Axis between Epithelial Splicing Regulatory Proteins and Estrogen Receptor α Modulates the Alternative Transcriptome of Luminal Breast Cancer.

Jamal Elhasnaoui, Giulio Ferrero, Valentina Miano, Lorenzo Franchitti, Isabella Tarulli, Lucia Coscujuela Tarrero, Santina Cutrupi, Michele De Bortoli

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jamal ElhasnaouiDepartment of Clinical and Biological Sciences, School of Medicine, University of Turin, Orbassano, 10043 Turin, Italy.ORCID 0000-0001-9311-0417
Giulio FerreroDepartment of Clinical and Biological Sciences, School of Medicine, University of Turin, Orbassano, 10043 Turin, Italy.ORCID 0000-0002-4580-0680
Valentina MianoDivision of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.ORCID 0000-0002-0260-5885
Lorenzo FranchittiDepartment of Clinical and Biological Sciences, School of Medicine, University of Turin, Orbassano, 10043 Turin, Italy.
Isabella TarulliDepartment of Clinical and Biological Sciences, School of Medicine, University of Turin, Orbassano, 10043 Turin, Italy.ORCID 0000-0003-4807-081X
Lucia Coscujuela TarreroCenter of Genomic Science of IIT@SEMM, Italian Institute of Technologies, 20139 Milan, Italy.ORCID 0000-0001-5889-6100
Santina CutrupiDepartment of Clinical and Biological Sciences, School of Medicine, University of Turin, Orbassano, 10043 Turin, Italy.ORCID 0000-0002-2358-5852
Michele De BortoliDepartment of Clinical and Biological Sciences, School of Medicine, University of Turin, Orbassano, 10043 Turin, Italy.
University of Turin · ITCandiolo Cancer Institute · ITUniversity of Cambridge · GB

Funding

Fondazione CRT 2017.0823Italian Association for Cancer Research IG15600University of Turin 2019 Local Research funding
6 · The paper itself

Abstract

Epithelial splicing regulatory proteins 1 and 2 (ESRP1/2) control the splicing pattern during epithelial to mesenchymal transition (EMT) in a physiological context and in cancer, including breast cancer (BC). Here, we report that

Indexed as

Breast NeoplasmsAlternative SplicingCell Line, TumorEpithelial-Mesenchymal TransitionEstrogen Receptor alphaFemaleGene Expression Regulation, NeoplasticHumansRNA-Binding ProteinsTranscription FactorsTranscriptomeEstrogen Receptor alphaRNA-Binding ProteinsTranscription Factorsalternative splicingbreast cancerEMT splicing signatureESRP1ESRP2Rac1Rac1b

Identifiers

PMID35887187
PMCPMC9319905
OpenAlexW4285732848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.