Evidence map›Paper›PMID 35887149›Full record

ArticleInternational journal of molecular sciences2022

Diego Camuzi, Luisa Aguirre Buexm, Simone de Queiroz Chaves Lourenço, Rachele Grazziotin, Simone Guaraldi, Priscila Valverde, Davy Rapozo, Jill M Brooks, Hisham Mehanna, Luis Felipe Ribeiro Pinto and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Survivin degradation by bergenin overcomes pemetrexed resistance.Cellular oncology (Dordrecht, Netherlands) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Diego CamuziMolecular Carcinogenesis Program, Brazilian National Cancer Institute, Rio de Janeiro 20231-050, Brazil.
Luisa Aguirre BuexmMolecular Carcinogenesis Program, Brazilian National Cancer Institute, Rio de Janeiro 20231-050, Brazil.
Simone de Queiroz Chaves LourençoDepartment of Pathology, Dental School, Fluminense Federal University, Niterói 24040-110, Brazil.
Rachele GrazziotinMolecular Carcinogenesis Program, Brazilian National Cancer Institute, Rio de Janeiro 20231-050, Brazil.ORCID 0000-0001-6184-4504
Simone GuaraldiMolecular Carcinogenesis Program, Brazilian National Cancer Institute, Rio de Janeiro 20231-050, Brazil.
Priscila ValverdePathology Division, National Cancer Institute, Rio de Janeiro 20230-130, Brazil.
Davy RapozoPathology Division, National Cancer Institute, Rio de Janeiro 20230-130, Brazil.
Jill M BrooksInstitute of Head and Neck Studies and Education (InHANSE), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Hisham MehannaInstitute of Head and Neck Studies and Education (InHANSE), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0002-5544-6224
Luis Felipe Ribeiro PintoMolecular Carcinogenesis Program, Brazilian National Cancer Institute, Rio de Janeiro 20231-050, Brazil.
Sheila Coelho Soares-LimaMolecular Carcinogenesis Program, Brazilian National Cancer Institute, Rio de Janeiro 20231-050, Brazil.
Instituto Nacional de Câncer - INCA · BRUniversidade Federal Fluminense · BRUniversity of Birmingham · GBUniversidade do Estado do Rio de Janeiro · BR

Funding

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/202.918/2019National Council for Scientific and Technological Development 407992/2016-2
6 · The paper itself

Abstract

Squamous cell carcinoma is the main histological tumor type in the upper aerodigestive tract (UADT), including the esophagus (ESCC) and the head and neck sites, as well as the oral cavity (OCSCC), larynx (LSCC) and oropharynx (OPSCC). These tumors are induced by alcohol and tobacco exposure, with the exception of a subgroup of OPSCC linked to human papillomavirus (HPV) infection. Few genes are frequently mutated in UADT tumors, pointing to other molecular mechanisms being involved during carcinogenesis. The F-box and leucine-rich repeat protein 7 (FBXL7) is a potential tumor-suppressing gene, one that is frequently hypermethylated in pancreatic cancer and where the encoded protein promotes the degradation of AURKA, BIRC5 and c-SRC. Thus, the aim of this study was to evaluate the methylation and expression profile of

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsPapillomavirus InfectionsAurora Kinase ADNA MethylationF-Box ProteinsHumansRespiratory SystemAurora Kinase AF-Box ProteinsFBXL7 protein, humanAURKAcancerDNA methylationesophagusFBXL7head and neckHPVsquamous cell carcinomaSurvivin

Identifiers

PMID35887149
PMCPMC9316635
OpenAlexW4285589649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.