Evidence map›Paper›PMID 35887110›Full record

ArticleInternational journal of molecular sciences2022

Antifungal Effect of Penicillamine Due to the Selective Targeting of L-Homoserine

Aleksandra Kuplińska, Kamila Rząd, Marek Wojciechowski, Sławomir Milewski, Iwona Gabriel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aleksandra KuplińskaDepartment of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 80-233 Gdansk, Poland.
Kamila RządDepartment of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 80-233 Gdansk, Poland.
Marek WojciechowskiDepartment of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 80-233 Gdansk, Poland.
Sławomir MilewskiDepartment of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 80-233 Gdansk, Poland.ORCID 0000-0003-2616-4495
Iwona GabrielDepartment of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, 80-233 Gdansk, Poland.ORCID 0000-0003-0833-5596
Gdańsk University of Technology · PL

Funding

National Science Center UMO-2020/39/B/NZ7/01519
6 · The paper itself

Abstract

Due to the apparent similarity of fungal and mammalian metabolic pathways, the number of established antifungal targets is low, and the identification of novel ones is highly desirable. The results of our studies, presented in this work, indicate that the fungal biosynthetic pathway of L-methionine, an amino acid essential for humans, seems to be an attractive perspective. The

Indexed as

Antifungal AgentsHomoserineAcetyltransferasesAnimalsEscherichia coliHumansMammalsPenicillamineAcetyltransferasesAntifungal AgentsHomoserinehomoserine O-acetyltransferasePenicillamineantifungal targetCandida albicansL-homoserine O-acetyltransferaseL-methionine biosynthesis

Identifiers

PMID35887110
PMCPMC9317633
OpenAlexW4286240453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.