Evidence map›Paper›PMID 35887096›Full record

ArticleInternational journal of molecular sciences2022

miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly.

Merit Wildung, Christian Herr, Dietmar Riedel, Cornelia Wiedwald, Alena Moiseenko, Fidel Ramírez, Hataitip Tasena, Maren Heimerl, Mihai Alevra, Naira Movsisyan and 18 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. S100A8Frontiers in immunology · 2026
    Article
  3. Article
  4. Article
  5. Silicosis: from pathogenesis to therapeutics.Frontiers in pharmacology · 2025
    Review
  6. Airway ciliated cells in adult lung homeostasis and COPD.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 8 institutions in 3 countries.

Merit WildungMolecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany.
Christian HerrDepartment of Internal Medicine V, Saarland University, 66421 Homburg, Germany.ORCID 0000-0001-9422-6569
Dietmar RiedelLaboratory for Electron Microscopy, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany.ORCID 0000-0003-2970-6894
Cornelia WiedwaldMolecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany.
Alena MoiseenkoImmunology & Respiratory Department, Boehringer Ingelheim Pharma GmbH, 88400 Biberach an der Riss, Germany.
Fidel RamírezGlobal Computational Biology and Digital Sciences Department, Boehringer Ingelheim Pharma GmbH, 88400 Biberach an der Riss, Germany.ORCID 0000-0002-9142-417X
Hataitip TasenaDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.
Maren HeimerlMolecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany.
Mihai AlevraInstitute of Neuro- and Sensory Physiology, Goettingen University, 37073 Goettingen, Germany.ORCID 0000-0002-1384-0071
Naira MovsisyanOncophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany.
Maike SchuldtMolecular Oncology, University Medical Center Goettingen, 37077 Goettingen, Germany.
Larisa Volceanov-HahnMolecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany.
Sharen ProvoostLaboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, 9000 Ghent, Belgium.
Tabea Nöthe-MenchenDepartment of General Pediatrics, University Hospital Muenster, 48149 Muenster, Germany.ORCID 0000-0002-0571-6767
Diana UrregoOncophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany.
Bernard FreytagMolecular Oncology, University Medical Center Goettingen, 37077 Goettingen, Germany.
Julia WallmeierDepartment of General Pediatrics, University Hospital Muenster, 48149 Muenster, Germany.
Christoph BeisswengerDepartment of Internal Medicine V, Saarland University, 66421 Homburg, Germany.ORCID 0000-0003-4391-3240
Robert BalsDepartment of Internal Medicine V, Saarland University, 66421 Homburg, Germany.
Maarten van den BergeGroningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.
Wim TimensDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.ORCID 0000-0002-4146-6363
Pieter S HiemstraDepartment of Pulmonology, Leiden University Medical Centre, 2333 Leiden, The Netherlands.ORCID 0000-0002-0238-5982
Corry-Anke BrandsmaDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.
Tania MaesLaboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, 9000 Ghent, Belgium.
Stefan AndreasMolecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany.ORCID 0000-0003-3918-6909
Irene H HeijinkDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9712 Groningen, The Netherlands.ORCID 0000-0002-1260-8932
Luis A PardoOncophysiology Group, Max Planck Institute for Multidisciplinary Sciences, 37075 Goettingen, Germany.
Muriel LizéMolecular & Experimental Pneumology Group, Clinic for Cardiology and Pneumology, University Medical Center Goettingen, 37075 Gottingen, Germany.ORCID 0000-0002-4954-3503
University of Göttingen · DEUniversity Medical Center Groningen · NLMax Planck Institute for Multidisciplinary SciencesBoehringer Ingelheim (Germany) · DESaarland University · DEGhent University Hospital · BEUniversity Hospital Münster · DELeiden University · NL

Funding

Deutsche Forschungsgemeinschaft LI 2405
6 · The paper itself

Abstract

Airway mucociliary regeneration and function are key players for airway defense and are impaired in chronic obstructive pulmonary disease (COPD). Using transcriptome analysis in COPD-derived bronchial biopsies, we observed a positive correlation between cilia-related genes and microRNA-449 (

Indexed as

MicroRNAsPulmonary Disease, Chronic ObstructiveAnimalsAurora Kinase ACiliaEpithelial CellsHistone Deacetylase 6MiceTubulinAurka protein, mouseAurora Kinase AHdac6 protein, mouseHistone Deacetylase 6MicroRNAsMirn449 microRNA, mouseTubulinairwayCDC20BciliogenesisCOPDlungmicroRNAmiR449miR449a

Identifiers

PMID35887096
PMCPMC9320302
OpenAlexW4285496148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.