Evidence map›Paper›PMID 35887084›Full record

ArticleInternational journal of molecular sciences2022

Trypsin-like Inhibitor Domain (TIL)-Harboring Protein Is Essential for

Chinmay Vijay Tikhe, Victor Cardoso-Jaime, Shengzhang Dong, Natalie Rutkowski, George Dimopoulos

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Transcriptome analysis ofCurrent research in parasitology & vector-borne diseases · 2025
    Article
  3. A Genome-Wide Analysis of Serine Protease Inhibitors inInternational journal of molecular sciences · 2023
    Article
  4. Article
  5. Editorial: Special Issue on the "Molecular Biology of Disease Vectors".International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chinmay Vijay TikheW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Victor Cardoso-JaimeW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0003-4605-092X
Shengzhang DongW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0002-8218-4688
Natalie RutkowskiW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
George DimopoulosW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0001-6755-8111
Johns Hopkins University · US

Funding

Aedes antiviral RNAi pathwayR01AI141532 · NIAID · JOHNS HOPKINS UNIVERSITY · PI George Dimopoulos, KEVIN M MYLES · 2019 to 2026
$4.6M
NIH HHS R01AI141532
6 · The paper itself

Abstract

Cysteine-rich trypsin inhibitor-like domain (TIL)-harboring proteins are broadly distributed in nature but remain understudied in vector mosquitoes. Here we have explored the biology of a TIL domain-containing protein of the arbovirus vector

Indexed as

AedesDengueVirus DiseasesAnimalsCysteineFemaleMaleMosquito VectorsReproductionTrypsinTrypsin InhibitorsCysteineTrypsinTrypsin InhibitorsAedes aegyptiCRISPR-Cas9denguemosquitoesreproductiontrypsin inhibitor

Identifiers

PMID35887084
PMCPMC9319116
OpenAlexW4285394052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.