Evidence map›Paper›PMID 35887056›Full record

ArticleInternational journal of molecular sciences2022

Effect of Haloperidol and Olanzapine on Hippocampal Cells' Proliferation in Animal Model of Schizophrenia.

Jana Osacka, Alexander Kiss, Zuzana Bacova, Andrej Tillinger

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jana OsackaBiomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Dúbravská Cesta 9, 845 05 Bratislava, Slovakia.ORCID 0000-0003-2144-0534
Alexander KissBiomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Dúbravská Cesta 9, 845 05 Bratislava, Slovakia.
Zuzana BacovaBiomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Dúbravská Cesta 9, 845 05 Bratislava, Slovakia.
Andrej TillingerBiomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Dúbravská Cesta 9, 845 05 Bratislava, Slovakia.ORCID 0000-0003-4643-7040
Slovak Academy of Sciences · SK

Funding

VEGA 2/0010/22VEGA 2/0037/19
6 · The paper itself

Abstract

Aberrant neurogenesis in the subventricular zone (SVZ) and hippocampus (HIP) contributes to schizophrenia pathogenesis. Haloperidol (HAL) and olanzapine (OLA), commonly prescribed antipsychotics for schizophrenia treatment, affect neurogenesis too. The effect of HAL and OLA on an mHippoE-2 cell line was studied in vitro where we measured the cell number and projection length. In vivo, we studied the gene expression of

Indexed as

Antipsychotic AgentsSchizophreniaAnimalsBenzodiazepinesCell ProliferationDisease Models, AnimalDizocilpine MaleateHaloperidolHippocampusOlanzapineAntipsychotic AgentsBenzodiazepinesDizocilpine MaleateHaloperidolOlanzapinehaloperidolhippocampusneurogenesisolanzapinesubventricular zone

Identifiers

PMID35887056
PMCPMC9323809
OpenAlexW4285092788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.